Publications

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration.

Pharmacological reviews

A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Quality of life and consequences for daily life of familial adenomatous polyposis (FAP) family members.

Psycho-oncology

Distress in partners of individuals diagnosed with or at high risk of developing tumors due to rare hereditary cancer syndromes.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

Bioconjugate chemistry

Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.

18-05-2011

Cancer

Overall survival and PD-L1 expression in metastasized malignant melanoma.

15-05-2011

Human antibodies

CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis.

12-05-2011

Human antibodies

The pharmacokinetics of ¹²⁴I-rituximab in patients with rheumatoid arthritis.

12-05-2011

Tumori

Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report.

03-05-2011

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in endometrial carcinoma 1 (PORTEC-1) trial.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices.

International journal of radiation oncology, biology, physics

Three-dimensional analysis of recurrence patterns in rectal cancer: the cranial border in hypofractionated preoperative radiotherapy can be lowered.

The Journal of pathology

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.

Disease models & mechanisms

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice.

The Journal of pathology

Development of metastatic HER2(+) breast cancer is independent of the adaptive immune system.

Drug metabolism and disposition: the biological fate of chemicals

Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.

Breast cancer research and treatment

Sentinel node micrometastases in breast cancer do not affect prognosis: a population-based study.

PloS one

A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range.

29-04-2011

Cell

A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation.

15-04-2011

Journal of the National Cancer Institute

Independent prognostic value of screen detection in invasive breast cancer.

06-04-2011

Proceedings of the National Academy of Sciences of the United States of America

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.

05-04-2011

DNA repair

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.

03-04-2011

Fundamental & clinical pharmacology

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

Journal of analytical toxicology

Determination of platinum originating from carboplatin in human urine and canine excretion products by inductively coupled plasma mass spectrometry.

BJU international

Diabetes mellitus and health-related quality of life in prostate cancer: 5-year results from the Prostate Cancer Outcomes Study.

International journal of radiation oncology, biology, physics

Effects of setup errors and shape changes on breast radiotherapy.

EMBO reports

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.

Annals of oncology : official journal of the European Society for Medical Oncology

Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology

The relation between information provision and health-related quality of life, anxiety and depression among cancer survivors: a systematic review.

Nederlands tijdschrift voor geneeskunde

[Adult cancer patients are surviving longer in the Netherlands: 5-year survival rate increased by 12% between the periods 1989-1993 and 2004-2008].

31-03-2011

Cancer imaging : the official publication of the International Cancer Imaging Society

Radiofrequency ablation as a treatment tool for liver metastases of colorectal origin.

24-03-2011

Proceedings of the National Academy of Sciences of the United States of America

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.

15-03-2011

Nature medicine

Taming the dragon: genomic biomarkers to individualize the treatment of cancer.

The British journal of surgery

Toxicity and complications of preoperative chemoradiotherapy for locally advanced rectal cancer.

Head & neck

Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer.

European journal of cancer (Oxford, England : 1990)

Normative data for the EORTC QLQ-C30 and EORTC-sexuality items in the general Dutch population.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Magnetic resonance imaging response monitoring of breast cancer during neoadjuvant chemotherapy: relevance of breast cancer subtype.

20-02-2011

PloS one

Functional characterization of human cancer-derived TRKB mutations.

17-02-2011

PloS one

Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue.

11-02-2011

Epigenetics & chromatin

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.

03-02-2011

Journal of biomedical optics

Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model.

02-02-2011

Psycho-oncology

Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors--a meta-analysis.

Current clinical pharmacology

Pharmacodynamic biomarkers in model-based drug development in oncology.

Archives of dermatology

Impact of melanoma on patients' lives among 562 survivors: a Dutch population-based study.

Breast cancer research and treatment

Body weight and risk of breast cancer in BRCA1/2 mutation carriers.

Medical physics

Simplifying EPID dosimetry for IMRT treatment verification.

Nature structural & molecular biology

Structural basis of substrate discrimination and integrin binding by autotaxin.

Cell cycle (Georgetown, Tex.)

Screening for modulators of cisplatin sensitivity: unbiased screens reveal common themes.