Publications

Clinical cancer research : an official journal of the American Association for Cancer Research

PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.

01-03-2017

Journal of pharmaceutical and biomedical analysis

Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.

20-02-2017

Drug delivery and translational research

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar.

01-02-2017

Breast cancer research and treatment

An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.

01-02-2017

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine.

01-01-2017

Journal of clinical pharmacology

Clinical Pharmacokinetics of Vemurafenib in BRAF-Mutated Melanoma Patients.

01-01-2017

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months.

20-12-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients.

01-12-2016

Therapeutic drug monitoring

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry.

01-12-2016

Cancer treatment reviews

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

01-11-2016

Cancer treatment reviews

Inventory of oral anticancer agents: Pharmaceutical formulation aspects with focus on the solid dispersion technique.

01-11-2016

Journal of pharmaceutical and biomedical analysis

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

25-10-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasma.

15-10-2016

Journal of controlled release : official journal of the Controlled Release Society

Inherent formulation issues of kinase inhibitors.

10-10-2016

Cancer chemotherapy and pharmacology

Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines.

01-10-2016

The oncologist

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges.

01-10-2016

Journal of clinical pharmacology

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.

01-10-2016

Investigational new drugs

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors.

01-10-2016

International journal of pharmaceutics

Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel.

25-09-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma.

15-09-2016

British journal of clinical pharmacology

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.

01-09-2016

Journal of pharmaceutical analysis

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar.

01-08-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry.

01-08-2016

Journal of pharmaceutical and biomedical analysis

Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma.

15-07-2016

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Reply to T. Magnes et al.

10-07-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma.

15-06-2016

Journal of pharmaceutical and biomedical analysis

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

05-06-2016

Neuro-oncology

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors.

01-06-2016

Cancer chemotherapy and pharmacology

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine.

01-06-2016

Investigational new drugs

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison.

01-06-2016

Journal of pharmacokinetics and pharmacodynamics

The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

01-06-2016

European journal of clinical pharmacology

Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment.

01-06-2016

International journal of cancer

Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity.

01-06-2016

Drug metabolism reviews

Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review.

01-05-2016

British journal of clinical pharmacology

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

01-05-2016

Cancer

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study.

01-05-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Corrigendum to "Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine" [J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 893-894 (2012) 92-100].

01-05-2016

Antimicrobial agents and chemotherapy

Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection.

01-04-2016

Journal of neurology

Strategies to target drugs to gliomas and CNS metastases of solid tumors.

01-03-2016

The AAPS journal

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer.

01-03-2016

Lung cancer (Amsterdam, Netherlands)

Crizotinib-induced fatal fulminant liver failure.

01-03-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction.

15-02-2016

Investigational new drugs

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.

01-02-2016

European journal of cancer (Oxford, England : 1990)

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care.

01-02-2016

International journal of cancer

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.

01-02-2016

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

25-01-2016

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

20-01-2016

Cancers

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer.

02-01-2016

International journal of cancer

Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.

01-01-2016

Bioanalysis

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS.

15-12-2015