Publications

European journal of clinical pharmacology

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases.

01-06-2018

British journal of clinical pharmacology

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides.

01-06-2018

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Molecular Imaging of ABCB1 and ABCG2 Inhibition at the Human Blood-Brain Barrier Using Elacridar and ¹¹C-Erlotinib PET.

01-06-2018

Investigational new drugs

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

01-06-2018

Cell

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

31-05-2018

Bioorganic & medicinal chemistry letters

A multi-gram-scale stereoselective synthesis of Z-endoxifen.

01-05-2018

Clinical pharmacokinetics

Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial.

01-05-2018

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

15-04-2018

Clinical pharmacokinetics

PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer.

01-04-2018

Biomedical chromatography : BMC

Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.

01-04-2018

Therapeutic drug monitoring

Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS.

01-04-2018

Journal of pharmaceutical and biomedical analysis

Ultra-sensitive LC-MS/MS method for the quantification of gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma for a microdose clinical trial.

20-03-2018

Journal of neuro-oncology

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid.

01-03-2018

Pharmacological research

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice.

01-03-2018

Clinical pharmacokinetics

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.

01-02-2018

Journal of pharmaceutical and biomedical analysis

Thermal stability study of crystalline and novel spray-dried amorphous nilotinib hydrochloride.

30-01-2018

Journal of pharmaceutical and biomedical analysis

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of Dexamphetamine in human plasma.

30-01-2018

International journal of cancer

The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors.

15-01-2018

Cancer chemotherapy and pharmacology

Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a ¹⁴C-microtracer and therapeutic dose in cancer patients.

01-01-2018

Cancer chemotherapy and pharmacology

Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a ¹⁴C-microtracer and therapeutic dose in cancer patients.

01-01-2018

Annals of oncology : official journal of the European Society for Medical Oncology

DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update.

01-12-2017

Cancer chemotherapy and pharmacology

Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.

01-12-2017

Investigational new drugs

Human mass balance study and metabolite profiling of ¹⁴C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.

01-12-2017

Thrombosis and haemostasis

Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry.

01-12-2017

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma.

15-11-2017

Clinical pharmacology and therapeutics

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.

01-11-2017

The Journal of antimicrobial chemotherapy

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

01-11-2017

European journal of cancer (Oxford, England : 1990)

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir.

01-11-2017

European journal of cancer (Oxford, England : 1990)

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

01-11-2017

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine.

25-10-2017

Molecular pharmaceutics

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

02-10-2017

Investigational new drugs

Pharmacokinetics and excretion of ¹⁴C-Plitidepsin in patients with advanced cancer.

01-10-2017

The pharmacogenomics journal

Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies.

01-10-2017

The oncologist

Fixed Dosing of Monoclonal Antibodies in Oncology.

01-10-2017

Oncotarget

Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice.

22-09-2017

BMC cancer

Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter study.

15-09-2017

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction.

01-09-2017

Clinical pharmacokinetics

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing.

01-09-2017

Pharmaceutical research

High-Tech Drugs in Creaky Formulations.

01-09-2017

International journal of pharmaceutics

Improving the solubility of nilotinib through novel spray-dried solid dispersions.

30-08-2017

Investigational new drugs

Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II.

01-08-2017

The oncologist

BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies.

01-07-2017

Pharmacological research

Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation.

01-06-2017

Therapeutic drug monitoring

Development and Validation of an LC-MS/MS Method for the Simultaneous Quantification of Abiraterone, Enzalutamide, and Their Major Metabolites in Human Plasma.

01-06-2017

British journal of cancer

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.

23-05-2017

Drug development and industrial pharmacy

Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies.

01-04-2017

Therapeutic drug monitoring

Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring.

01-04-2017

FEBS open bio

The G2 checkpoint-a node-based molecular switch.

01-04-2017

Clinical pharmacokinetics

Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients.

01-03-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.

01-03-2017