Publications

European journal of cancer (Oxford, England : 1990)

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme.

Cancer chemotherapy and pharmacology

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.

EJNMMI radiopharmacy and chemistry

Automated synthesis and quality control of [^99mTc]Tc-PSMA for radioguided surgery (in a [⁶⁸Ga]Ga-PSMA workflow).

Die Pharmazie

Development and validation of an LC-MS/MS method for the quantification of imatinib and imatinib-d8 in human plasma for the support of an absolute bioavailability microdose trial.

06-04-2020

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

01-04-2020

Future oncology (London, England)

Vorinostat in patients with resistant BRAF^V600E mutated advanced melanoma: a proof of concept study.

01-04-2020

Journal of geriatric oncology

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials.

01-04-2020

International journal of cancer

P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib.

15-03-2020

Journal of clinical pharmacology

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development.

01-03-2020

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Use of leftovers of monoclonal antibody products after partial extraction - A microbiological safety study.

01-03-2020

Neurology

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases.

04-02-2020

International journal of clinical pharmacy

Follow up survey for implementation of fixed-dosing of monoclonal antibodies.

Future oncology (London, England)

Encorafenib, binimetinib and cetuximab combined therapy for patients with BRAFV600E mutant metastatic colorectal cancer.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors.

Clinical pharmacokinetics

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.

International journal of pharmaceutics

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554).

05-01-2020

Journal of pharmaceutical and biomedical analysis

Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry.

05-01-2020

Biomedical chromatography : BMC

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology.

01-01-2020

Biomedical chromatography : BMC

A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices.

01-01-2020

Pharmacotherapy

Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer.

01-12-2019

CPT: pharmacometrics & systems pharmacology

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.

01-12-2019

Pharmaceutical research

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.

15-11-2019

Pharmaceutical research

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

15-10-2019

Clinical pharmacokinetics

Predictive Value of Microdose Pharmacokinetics.

01-10-2019

Clinical genitourinary cancer

Efficacy, Tolerance, and Plasma Levels of Abiraterone and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer With a Hepatic Transplant.

01-10-2019

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD-1 Expression Levels and PD-1 Receptor Occupancy by Nivolumab and Pembrolizumab.

01-10-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir.

15-09-2019

Journal of pharmaceutical and biomedical analysis

Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma.

10-09-2019

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study.

05-09-2019

Molecular pharmaceutics

P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability.

03-09-2019

European journal of clinical pharmacology

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine.

01-09-2019

Cancer chemotherapy and pharmacology

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.

01-09-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium.

01-09-2019

The Journal of biological chemistry

The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity.

23-08-2019

Analytical and bioanalytical chemistry

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry.

Pharmacological research

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.