Publications

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium.

01-09-2019

The Journal of biological chemistry

The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity.

23-08-2019

Analytical and bioanalytical chemistry

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry.

01-08-2019

Pharmacological research

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein).

01-08-2019

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence.

01-08-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

01-08-2019

Antimicrobial agents and chemotherapy

Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation.

01-07-2019

Journal of pharmaceutical and biomedical analysis

LC-MS/MS assay for the quantification of testosterone, dihydrotestosterone, androstenedione, cortisol and prednisone in plasma from castrated prostate cancer patients treated with abiraterone acetate or enzalutamide.

05-06-2019

BMC cancer

Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review.

30-05-2019

International journal of cancer

Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis.

01-05-2019

Drugs & aging

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice.

01-04-2019

Cancer medicine

Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort.

01-04-2019

Clinical genitourinary cancer

Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer Undergoing Hemodialysis.

01-04-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

15-03-2019

Archives of toxicology

ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.

01-03-2019

Prostate cancer and prostatic diseases

Impact of age on exposure to oral antiandrogen therapies in clinical practice.

01-03-2019

Clinical pharmacokinetics

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology.

01-03-2019

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

01-03-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.

01-03-2019

International journal of pharmaceutics

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice.

10-02-2019

Journal of pharmaceutical and biomedical analysis

Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-methyl-2'-deoxycytidine.

05-02-2019

Journal of pharmaceutical and biomedical analysis

Enzyme linked immunosorbent assay for the quantification of nivolumab and pembrolizumab in human serum and cerebrospinal fluid.

05-02-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors.

01-02-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology.

01-02-2019

Pharmaceutical research

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study.

07-01-2019

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling.

01-01-2019

Journal of biotechnology

Small-scale GMP production of plasmid DNA using a simplified and fully disposable production method.

01-01-2019

European journal of cancer (Oxford, England : 1990)

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

01-01-2019

British journal of clinical pharmacology

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?

01-12-2018

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

01-12-2018

Investigational new drugs

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose.

01-12-2018

Breast (Edinburgh, Scotland)

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy.

01-12-2018

British journal of clinical pharmacology

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers.

01-12-2018

Journal of pharmaceutical and biomedical analysis

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates.

30-11-2018

Molecular pharmaceutics

ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.

05-11-2018

Molecular pharmaceutics

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability.

05-11-2018

The Lancet. Oncology

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

01-11-2018

Breast cancer research and treatment

Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen.

01-11-2018

Pharmacological research

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability.

01-11-2018

International journal of cancer

P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.

15-10-2018

Nucleosides, nucleotides & nucleic acids

Development and validation of a quantitative method for thymidine phosphorylase activity in peripheral blood mononuclear cells.

05-10-2018

Journal of pharmaceutical and biomedical analysis

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine.

05-09-2018

Cancer chemotherapy and pharmacology

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of ¹⁴C-plitidepsin.

01-09-2018

The Journal of antimicrobial chemotherapy

Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships.

01-08-2018

Marine drugs

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment.

23-07-2018

Scientific reports

Buparlisib is a brain penetrable pan-PI3K inhibitor.

17-07-2018

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry.

15-07-2018

Contact dermatitis

Palladium-induced granulomas analysed with inductively coupled plasma mass spectrometry.

01-07-2018

Neoplasia (New York, N.Y.)

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2.

01-07-2018

Frontiers in cellular and infection microbiology

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

19-06-2018