Publications

Molecular cancer therapeutics

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.

Molecular cancer therapeutics

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.

Antimicrobial agents and chemotherapy

Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology.

10-07-2008

Biomarker insights

Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk.

02-07-2008

Anti-cancer drugs

The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass spectrometry.

01-07-2008

British journal of cancer

Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.

17-06-2008

Clinical pharmacology and therapeutics

PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression.

Pharmacogenetics and genomics

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide.

Clinical cancer research : an official journal of the American Association for Cancer Research

Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

Proteomics. Clinical applications

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer.

Analytical and bioanalytical chemistry

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.

01-05-2008

Nutrition and cancer

Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk.

30-04-2008

British journal of cancer

A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours.

22-04-2008

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.

01-04-2008

Clinical drug investigation

Carboplatin dosage formulae can generate inaccurate predictions of Carboplatin exposure in carboplatin/paclitaxel combination regimens.

29-03-2008

Molecular pharmacology

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

01-03-2008

Antimicrobial agents and chemotherapy

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin.

01-03-2008

The oncologist

Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy.

01-03-2008

Journal of pharmaceutical and biomedical analysis

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry.

13-02-2008

BMC bioinformatics

Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spectrometry data.

07-02-2008

Rapid communications in mass spectrometry : RCM

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin given intravesically.

31-01-2008

Mass spectrometry reviews

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research.

31-01-2008

BMC medical genomics

Comparing the old and new generation SELDI-TOF MS: implications for serum protein profiling.

31-01-2008

The oncologist

Application of PET/CT in the development of novel anticancer drugs.

01-01-2008

Molecular cancer therapeutics

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.

01-12-2007

Clinical pharmacokinetics

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

22-11-2007

Rapid communications in mass spectrometry : RCM

Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

17-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development group.

British journal of clinical pharmacology

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.

The Journal of clinical investigation

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.