Publications

Clinical cancer research : an official journal of the American Association for Cancer Research

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development group.

01-11-2007

British journal of clinical pharmacology

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.

01-11-2007

The Journal of clinical investigation

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

01-11-2007

Biomedical chromatography : BMC

Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography.

01-11-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.

01-11-2007

Cancer chemotherapy and pharmacology

Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours.

01-10-2007

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry.

01-09-2007

AAPS PharmSciTech

Development of a bladder instillation of the indoloquinone anticancer agent EO-9 using tert-butyl alcohol as lyophilization vehicle.

03-08-2007

Investigational new drugs

Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.

01-08-2007

The oncologist

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

01-08-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors.

01-08-2007

International archives of occupational and environmental health

Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry.

01-08-2007

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).

01-07-2007

Biomedical chromatography : BMC

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography.

01-07-2007

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.

20-06-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.

01-06-2007

Investigational new drugs

Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors.

01-06-2007

American journal of physiology. Cell physiology

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

01-06-2007

Clinical cancer research : an official journal of the American Association for Cancer Research

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.

15-05-2007

Cancer chemotherapy and pharmacology

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate.

01-05-2007

Cancer chemotherapy and pharmacology

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.

01-05-2007

Rapid communications in mass spectrometry : RCM

Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry.

06-04-2007

Molecular diagnosis & therapy

Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity.

03-04-2007

Pharmaceutical research

Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis.

01-03-2007

Nederlands tijdschrift voor geneeskunde

[Management recommendations in patients with methotrexate intoxication].

10-02-2007

Molecular and cellular biology

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.

01-02-2007

Cancer biomarkers : section A of Disease markers

SELDI-TOF MS serum protein profiles in breast cancer: assessment of robustness and validity.

01-02-2007

Investigational new drugs

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype.

01-02-2007

Laboratory investigation; a journal of technical methods and pathology

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations.

01-02-2007

International journal of pharmaceutics

EO-9 bladder instillations: formulation selection based on stability characteristics and in vitro simulation studies.

01-02-2007

Journal of pharmaceutical and biomedical analysis

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.

04-01-2007

Molecular pharmacology

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.

01-01-2007

Cancer chemotherapy and pharmacology

A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.

01-01-2007

European journal of cancer (Oxford, England : 1990)

Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies.

01-12-2006

Journal of mass spectrometry : JMS

Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

01-12-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Flat dosing of carboplatin is justified in adult patients with normal renal function.

01-11-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.

15-10-2006

British journal of cancer

Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer.

09-10-2006

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function.

01-10-2006

Journal of pharmacokinetics and pharmacodynamics

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam.

01-10-2006

Clinical cancer research : an official journal of the American Association for Cancer Research

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel.

01-10-2006

Die Pharmazie

Pharmaceutical development, quality control, stability and compatibility of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum antineoplastic agent AP5346.

01-10-2006

British journal of cancer

A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer.

18-09-2006

Journal of mass spectrometry : JMS

Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.

01-09-2006

Cancer treatment reviews

Future opportunities in preventing cisplatin induced ototoxicity.

01-08-2006

Basic & clinical pharmacology & toxicology

Interactions of serum albumin, valproic acid and carbamazepine with the pharmacokinetics of phenytoin in cancer patients.

01-08-2006

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours.

01-08-2006

European journal of clinical pharmacology

Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.

01-08-2006

Expert review of neurotherapeutics

Blood-brain barrier and chemotherapeutic treatment of brain tumors.

01-08-2006