Publications

Journal of clinical laboratory analysis

Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.

01-01-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates.

15-12-2011

Bioanalysis

Bioanalytical aspects of clinical mass balance studies in oncology.

01-12-2011

Cancer treatment reviews

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials.

01-12-2011

Journal of cancer research and clinical oncology

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer.

01-12-2011

International journal of pharmaceutics

Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001).

28-11-2011

Lung cancer (Amsterdam, Netherlands)

Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy.

01-11-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry.

15-10-2011

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial.

10-10-2011

Investigational new drugs

Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice.

01-10-2011

Journal of analytical toxicology

Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.

01-10-2011

International journal of pharmaceutics

Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis.

20-09-2011

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.

15-09-2011

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma.

01-09-2011

Clinical pharmacology and therapeutics

Population pharmacokinetic-pharmacodynamic analysis of trastuzumab-associated cardiotoxicity.

01-07-2011

The oncologist

Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects.

11-06-2011

The oncologist

Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism.

11-06-2011

The oncologist

Part 2: pharmacogenetic variability in drug transport and phase I anticancer drug metabolism.

03-06-2011

The oncologist

Part 1: background, methodology, and clinical adoption of pharmacogenetics.

03-06-2011

The oncologist

Trastuzumab.

03-06-2011

The AAPS journal

Evaluation of α2-integrin expression as a biomarker for tumor growth inhibition for the investigational integrin inhibitor E7820 in preclinical and clinical studies.

01-06-2011

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration.

01-06-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

01-06-2011

Journal of pharmaceutical and biomedical analysis

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

01-06-2011

Clinical cancer research : an official journal of the American Association for Cancer Research

Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer.

15-05-2011

Human antibodies

CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis.

12-05-2011

Human antibodies

The pharmacokinetics of ¹²⁴I-rituximab in patients with rheumatoid arthritis.

12-05-2011

Human antibodies

The pharmacokinetics of ¹³¹I-rituximab in a patient with CD20 positive non-Hodgkin Lymphoma: evaluation of the effect of radioiodination on the biological properties of rituximab.

12-05-2011

Tumori

Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report.

03-05-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices.

01-05-2011

Drug metabolism and disposition: the biological fate of chemicals

Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.

01-05-2011

Fundamental & clinical pharmacology

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

01-04-2011

Journal of analytical toxicology

Determination of platinum originating from carboplatin in human urine and canine excretion products by inductively coupled plasma mass spectrometry.

01-04-2011

Current clinical pharmacology

Pharmacodynamic biomarkers in model-based drug development in oncology.

01-02-2011

Journal of pharmaceutical and biomedical analysis

Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry.

25-01-2011

Computer methods and programs in biomedicine

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

01-01-2011

Cancer chemotherapy and pharmacology

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.

01-01-2011

Analytica chimica acta

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.

17-12-2010

International journal of cancer

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

15-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages.

01-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice.

01-09-2010

Current clinical pharmacology

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents.

01-08-2010

Clinical pharmacokinetics

Clinical pharmacokinetics of therapeutic monoclonal antibodies.

01-08-2010

Current clinical pharmacology

Inducing synthetic lethality using PARP inhibitors.

01-08-2010

Journal of pharmacokinetics and pharmacodynamics

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080.

01-08-2010

Current clinical pharmacology

DNA vaccination in oncology: current status, opportunities and perspectives.

01-08-2010

Current clinical pharmacology

Personalized medicine in oncology: a personal view with myths and facts.

01-08-2010

Mass spectrometry reviews

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.

14-07-2010

Annals of oncology : official journal of the European Society for Medical Oncology

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.

01-07-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

01-07-2010