Publications

European journal of cancer (Oxford, England : 1990)

Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo.

01-05-2013

Clinical cancer research : an official journal of the American Association for Cancer Research

Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues.

15-04-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.

15-04-2013

Investigational new drugs

Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole.

01-04-2013

Therapeutic drug monitoring

Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring.

01-04-2013

Biomedical chromatography : BMC

Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.

01-04-2013

International journal of radiation oncology, biology, physics

Simultaneous integrated boost-intensity modulated radiation therapy with concomitant capecitabine and mitomycin C for locally advanced anal carcinoma: a phase 1 study.

01-04-2013

Drugs in R&D

Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy.

01-03-2013

Analytical and bioanalytical chemistry

Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells.

01-03-2013

Analytical and bioanalytical chemistry

Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination.

01-03-2013

British journal of clinical pharmacology

Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin.

01-02-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Sensitive method for plasma and tumor Ko143 quantification using reversed-phase high-performance liquid chromatography and fluorescence detection.

15-01-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry.

15-01-2013

Cancer chemotherapy and pharmacology

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023.

01-01-2013

Therapeutic advances in medical oncology

Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients.

01-01-2013

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel.

01-01-2013

Pharmaceutical research

Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab.

01-12-2012

Cancer chemotherapy and pharmacology

Pharmacokinetics of eribulin mesylate in patients with solid tumors and hepatic impairment.

01-12-2012

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion.

01-12-2012

BMJ (Clinical research ed.)

Commentary: Substandard medicines are the priority for neglected tropical diseases.

14-11-2012

Molecular pharmaceutics

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.

05-11-2012

Cancer chemotherapy and pharmacology

Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors.

01-11-2012

Bioanalysis

Quantitative determination of erlotinib and O-desmethyl erlotinib in human EDTA plasma and lung tumor tissue.

01-11-2012

Molecular pharmaceutics

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

04-09-2012

The AAPS journal

Performance of methods for handling missing categorical covariate data in population pharmacokinetic analyses.

01-09-2012

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signal-regulated kinase and DNA in circulating tumor cells.

01-08-2012

Investigational new drugs

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152).

01-08-2012

British journal of clinical pharmacology

Model-based treatment optimization of a novel VEGFR inhibitor.

01-08-2012

Investigational new drugs

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies.

01-08-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Determination of NVP-BEZ235, a dual PI3K and mTOR inhibitor, in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography with fluorescence detection.

15-07-2012

Drug metabolism and disposition: the biological fate of chemicals

Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine.

01-07-2012

The oncologist

Concise drug review: pazopanib and axitinib.

27-06-2012

Breast cancer research and treatment

Importance of highly selective LC-MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen.

01-06-2012

Cancer chemotherapy and pharmacology

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study.

01-06-2012

Journal of palliative care

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer.

16-05-2012

British journal of cancer

A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours.

08-05-2012

Cancer

Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study.

01-05-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine.

15-04-2012

The oncologist

Lapatinib for advanced or metastatic breast cancer.

06-04-2012

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib.

01-04-2012

Investigational new drugs

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

01-04-2012

Journal of clinical pharmacology

From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies.

01-03-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

01-03-2012

Journal of clinical pharmacology

Model-based evaluation of similarity in pharmacokinetics of two formulations of the blood-derived plasma product c1 esterase inhibitor.

01-02-2012

Drug metabolism and disposition: the biological fate of chemicals

Mass balance study of [¹⁴C]eribulin in patients with advanced solid tumors.

01-02-2012

Cancer chemotherapy and pharmacology

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine.

01-01-2012

International journal of cancer

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

01-01-2012

Journal of clinical laboratory analysis

Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.

01-01-2012

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates.

15-12-2011

Bioanalysis

Bioanalytical aspects of clinical mass balance studies in oncology.

01-12-2011