Publications

Bioanalysis

Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review.

01-09-2014

Nederlands tijdschrift voor geneeskunde

[Hyperglycaemia during treatment with everolimus].

15-08-2014

European journal of cancer (Oxford, England : 1990)

Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies.

01-08-2014

European journal of cancer (Oxford, England : 1990)

Therapeutic drug monitoring in cancer--are we missing a trick?

01-08-2014

European journal of cancer (Oxford, England : 1990)

Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics.

01-08-2014

Breast cancer research and treatment

Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen.

01-07-2014

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

15-06-2014

Therapeutic drug monitoring

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care.

01-06-2014

British journal of cancer

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.

27-05-2014

Clinical cancer research : an official journal of the American Association for Cancer Research

ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.

15-05-2014

British journal of cancer

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.

13-05-2014

Current clinical pharmacology

Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer.

01-05-2014

Anti-cancer drugs

Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review.

01-05-2014

Clinical pharmacokinetics

Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets.

01-04-2014

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma.

01-04-2014

Clinical pharmacology and therapeutics

Herb-drug interactions in oncology.

01-04-2014

Bioanalysis

Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays.

01-04-2014

BioMed research international

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy.

29-03-2014

International journal of cancer

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.

15-03-2014

Journal of pharmaceutical and biomedical analysis

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

01-03-2014

Molecular pharmacology

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

01-03-2014

Breast cancer research and treatment

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care.

01-02-2014

Journal of pharmaceutical sciences

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

01-02-2014

Biomedical chromatography : BMC

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

01-02-2014

Journal of pharmaceutical and biomedical analysis

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma.

01-01-2014

BMC cancer

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.

28-12-2013

European journal of clinical pharmacology

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome.

01-12-2013

Current opinion in pharmacology

Genetically modified mouse models for oral drug absorption and disposition.

01-12-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying olaparib in human plasma.

01-12-2013

Clinical therapeutics

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

01-12-2013

European journal of pharmacology

Taxanes: old drugs, new oral formulations.

05-10-2013

Cancer treatment reviews

Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities.

01-10-2013

Pharmacological research

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.

01-10-2013

Investigational new drugs

Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.

01-10-2013

Rapid communications in mass spectrometry : RCM

Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry.

15-09-2013

International journal of pharmaceutics

Long term stability of lyophilized plasmid DNA pDERMATT.

10-09-2013

International journal of cancer

Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.

01-09-2013

Gynecologic oncology

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

01-09-2013

The Journal of pharmacology and experimental therapeutics

Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinib.

01-09-2013

British journal of clinical pharmacology

Population pharmacokinetic-pharmacodynamic analysis for eribulin mesilate-associated neutropenia.

01-09-2013

Journal of clinical pharmacology

A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors.

01-08-2013

Vaccine

Transposon leads to contamination of clinical pDNA vaccine.

11-07-2013

British journal of clinical pharmacology

Optimizing drug development of anti-cancer drugs in children using modelling and simulation.

01-07-2013

Cancer treatment reviews

Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?

01-06-2013

Clinical pharmacokinetics

Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

01-06-2013

Drug delivery and translational research

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet.

01-06-2013

The oncologist

Concise drug review: azacitidine and decitabine.

15-05-2013

International journal of cancer

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.

15-05-2013

Nederlands tijdschrift voor geneeskunde

[Concomitant use of proton pump inhibitors and systemic corticosteroids].

10-05-2013

CNS oncology

Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

01-05-2013