Publications

British journal of clinical pharmacology

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer.

01-05-2010

Investigational new drugs

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

01-04-2010

Molecular pharmacology

Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.

01-04-2010

Investigational new drugs

Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.

01-04-2010

Oncology letters

Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer.

01-03-2010

AAPS PharmSciTech

Naked plasmid DNA formulation: effect of different disaccharides on stability after lyophilisation.

01-03-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

01-03-2010

Molecular cancer therapeutics

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

01-02-2010

Investigational new drugs

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents.

01-02-2010

Biomedical chromatography : BMC

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature.

01-01-2010

Nucleosides, nucleotides & nucleic acids

Facile small scale synthesis of nucleoside 5'-phosphate mixtures.

01-01-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.

01-01-2010

Clinical pharmacology and therapeutics

Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel.

01-01-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity.

15-12-2009

Journal of pharmaceutical and biomedical analysis

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

05-12-2009

Cancer research

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

01-12-2009

Cancer treatment reviews

High-grade glioma mouse models and their applicability for preclinical testing.

01-12-2009

Drug metabolism and disposition: the biological fate of chemicals

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.

01-12-2009

Biomedical chromatography : BMC

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.

01-12-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

01-11-2009

Journal of the American Society for Mass Spectrometry

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

01-11-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography.

01-11-2009

Journal of controlled release : official journal of the Controlled Release Society

DNA tattoo vaccination: effect on plasmid purity and transfection efficiency of different topoisoforms.

15-10-2009

Analytical and bioanalytical chemistry

Protein versus DNA as a marker for peripheral blood mononuclear cell counting.

01-10-2009

Rapid communications in mass spectrometry : RCM

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.

01-10-2009

Analytical biochemistry

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

01-10-2009

The International journal of biological markers

Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling.

30-09-2009

Human antibodies

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies.

05-09-2009

The oncologist

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature.

01-09-2009

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.

15-08-2009

Analytical biochemistry

Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

15-08-2009

The oncologist

Clinical experience with aurora kinase inhibitors: a review.

01-08-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors.

01-07-2009

Oncology reports

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.

01-07-2009

Breast cancer research and treatment

Clinical proteomics in breast cancer: a review.

01-07-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

15-06-2009

Cancer chemotherapy and pharmacology

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

01-06-2009

Analytical and bioanalytical chemistry

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

01-06-2009

Clinical chemistry and laboratory medicine

Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).

07-05-2009

Journal of chromatography. A

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.

10-04-2009

Cancer treatment reviews

The biological and clinical role of drug transporters at the intestinal barrier.

01-04-2009

Drug metabolism and disposition: the biological fate of chemicals

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors.

01-04-2009

Investigational new drugs

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

01-04-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.

01-04-2009

Acta oncologica (Stockholm, Sweden)

Persistent neuropathy after treatment with cisplatin and oxaliplatin.

25-03-2009

International journal of clinical pharmacology and therapeutics

Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.

01-03-2009

Rapid communications in mass spectrometry : RCM

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

01-03-2009

Journal of pharmaceutical and biomedical analysis

Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.

20-02-2009

Cancer chemotherapy and pharmacology

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa.

01-02-2009

Journal of pharmacokinetics and pharmacodynamics

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

01-02-2009