Publications

The Journal of pharmacology and experimental therapeutics

P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

Clinical cancer research : an official journal of the American Association for Cancer Research

Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer.

15-05-2011

Human antibodies

CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis.

12-05-2011

Human antibodies

The pharmacokinetics of ¹²⁴I-rituximab in patients with rheumatoid arthritis.

12-05-2011

Human antibodies

The pharmacokinetics of ¹³¹I-rituximab in a patient with CD20 positive non-Hodgkin Lymphoma: evaluation of the effect of radioiodination on the biological properties of rituximab.

12-05-2011

Tumori

Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report.

03-05-2011

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices.

01-05-2011

Drug metabolism and disposition: the biological fate of chemicals

Differential impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on axitinib brain accumulation and oral plasma pharmacokinetics.

01-05-2011

Fundamental & clinical pharmacology

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

01-04-2011

Journal of analytical toxicology

Determination of platinum originating from carboplatin in human urine and canine excretion products by inductively coupled plasma mass spectrometry.

01-04-2011

Current clinical pharmacology

Pharmacodynamic biomarkers in model-based drug development in oncology.

01-02-2011

Journal of pharmaceutical and biomedical analysis

Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry.

25-01-2011

Computer methods and programs in biomedicine

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

01-01-2011

Cancer chemotherapy and pharmacology

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor.

01-01-2011

Analytica chimica acta

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.

17-12-2010

International journal of cancer

Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

15-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages.

01-12-2010

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice.

01-09-2010

Current clinical pharmacology

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents.

Clinical pharmacokinetics

Clinical pharmacokinetics of therapeutic monoclonal antibodies.

Current clinical pharmacology

Inducing synthetic lethality using PARP inhibitors.

Journal of pharmacokinetics and pharmacodynamics

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080.

Current clinical pharmacology

DNA vaccination in oncology: current status, opportunities and perspectives.

Current clinical pharmacology

Personalized medicine in oncology: a personal view with myths and facts.

Mass spectrometry reviews

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.

14-07-2010

Annals of oncology : official journal of the European Society for Medical Oncology

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

Oncology reports

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry.

British journal of pharmacology

Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.