Wout Oosterheert
Mechanistic structural biology
Proteins are essential molecules that perform virtually every function within the cell. Our group aims to uncover the 3D-structures of protein complexes. This enables us to understand how our cells operate at the atomic level.
We are particularly interested in the mechanisms that underlie (cancer)-cell migration and adhesion. Specifically, we study how the cytoskeleton interacts with the cell membrane using a combination of cryo-electron microscopy and biophysical methods. Our research is driven by curiosity, but may ultimately also contribute to the development of novel anti-cancer drugs.
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Study on actin filament disassembly published in Cell
In this new study that wraps up Wout’s postdoctoral work, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
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