Microscope image of individual RNAs from two genes in yeast cells.

Tineke Lenstra

Transcription dynamics

Regulation of transcription (copying of a gene’s DNA) is essential for the normal growth and function of cells. In a single cell, transcription can show large fluctuations in activity over time, resulting in variability between cells in a population. Such variability can result in different cellular responses of individual cells, for example to drug treatment.

Our lab uses and develops single-molecule imaging techniques to visualize individual protein and RNA molecules in living cells. Our goal is to understand the mechanisms of transcription variation and dynamics in single cells.

This site uses cookies

This website uses cookies to ensure you get the best experience on our website.