Microscope image of individual RNAs from two genes in yeast cells.

Tineke Lenstra

Group leader

+31 20 512 7889 t.lenstra@nki.nl

Regulation of transcription (copying of a gene’s DNA) is essential for the normal growth and function of cells. In a single cell, transcription can show large fluctuations in activity over time, resulting in variability between cells in a population. Such variability can result in different cellular responses of individual cells, for example to drug treatment. Our lab uses and develops single-molecule imaging techniques to visualize individual protein and RNA molecules in living cells. Our goal is to understand the mechanisms of transcription variation and dynamics in single cells.


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