Cancer treatment induced Peripheral Neuropathy (CIPN) is a common side effect of cancer treatment. Although CIPN symptoms generally decrease over time, one in three patients continue to experience them more than 6 months after treatment, with a small chance of spontaneous recovery. Exercise has been suggested a promising non-pharmaceutical intervention, but current evidence is very limited and guidelines highlight this knowledge gap.
The SICILY study is a multicenter RCT that will include 136 individuals who completed curative neurotoxic systemic cancer treatment ≥6 months ago and experience CIPN-interference in daily life. They will receive a multimodal exercsise intervention (immediate or after waiting period) aimed at reducing CIPN burden. The intervention will be delivered by primary care physiotherapists via Onconet (www.onconet.nu) and occupational therapists.
The study is recruiting since September 2025
