Publications

Investigational new drugs

Mass balance and metabolite profiling of ¹⁴C-guadecitabine in patients with advanced cancer.

British journal of clinical pharmacology

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance.

Therapeutic drug monitoring

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs.

Cancer chemotherapy and pharmacology

Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.

01-07-2020

Clinical pharmacokinetics

Cost-Neutral Optimization of Pazopanib Exposure by Splitting Intake Moments: A Prospective Pharmacokinetic Study in Cancer Patients.

01-07-2020

Clinical pharmacokinetics

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors.

01-07-2020

Clinical pharmacokinetics

Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.

01-06-2020

Prostate cancer and prostatic diseases

Exposure-response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer.

01-06-2020

Acta physiologica (Oxford, England)

Doxorubicin-induced skeletal muscle atrophy: Elucidating the underlying molecular pathways.

01-06-2020

Pharmaceutical research

Phase I pharmacological study of continuous chronomodulated capecitabine treatment.

07-05-2020

CPT: pharmacometrics & systems pharmacology

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation.

01-05-2020

European journal of cancer (Oxford, England : 1990)

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme.

01-05-2020

Cancer chemotherapy and pharmacology

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.

01-05-2020

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

01-04-2020

Clinical pharmacokinetics

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation.

01-04-2020

Journal of geriatric oncology

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials.

01-04-2020

Journal of pharmaceutical and biomedical analysis

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma.

20-03-2020

Journal of clinical pharmacology

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development.

01-03-2020

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Use of leftovers of monoclonal antibody products after partial extraction - A microbiological safety study.

01-03-2020

The AAPS journal

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry.

06-02-2020

European journal of drug metabolism and pharmacokinetics

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.

01-02-2020

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors.

01-02-2020

Clinical pharmacokinetics

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia.

01-02-2020

British journal of clinical pharmacology

Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen.

01-01-2020

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children.

01-01-2020

Pharmaceutical research

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation.

26-12-2019

Pharmacotherapy

Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer.

01-12-2019

CPT: pharmacometrics & systems pharmacology

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.

01-12-2019

Pharmaceutical research

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study.

15-11-2019

Analytica chimica acta

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial.

08-11-2019

Pharmaceutical research

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

15-10-2019

Therapeutic drug monitoring

Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study.

Clinical pharmacokinetics

Predictive Value of Microdose Pharmacokinetics.

British journal of clinical pharmacology

Nonlinear protein binding of phenytoin in clinical practice: Development and validation of a mechanistic prediction model.

Nature

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.

Key Publication

Therapeutic drug monitoring

Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry.

Clinical cancer research : an official journal of the American Association for Cancer Research

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir.

15-09-2019

Journal of pharmaceutical and biomedical analysis

Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma.

10-09-2019

European journal of clinical pharmacology

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine.

Cancer chemotherapy and pharmacology

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes.

Acta psychiatrica Scandinavica

Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort).

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium.