Publications

Breast cancer research and treatment

The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer.

Pharmaceutical research

A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children.

Annals of oncology : official journal of the European Society for Medical Oncology

Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study.

The oncologist

A Single-arm Phase II Study Combining NLG207, a Nanoparticle Camptothecin, with Enzalutamide in Advanced Metastatic Castration-resistant Prostate Cancer Post-Enzalutamide.

02-09-2022

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Feasibility of therapeutic drug monitoring of sorafenib in patients with liver or thyroid cancer.

01-09-2022

Therapeutic drug monitoring

Everolimus Concentration in Saliva to Predict Stomatitis: A Feasibility Study in Patients with Cancer.

01-08-2022

Clinical and translational science

Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer.

01-08-2022

Clinical pharmacology and therapeutics

Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding: Results From a Case Series.

01-08-2022

Pharmaceuticals (Basel, Switzerland)

Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs.

13-07-2022

Cancer chemotherapy and pharmacology

Efficacy and toxicity of vemurafenib and cobimetinib in relation to plasma concentrations, after administration via feeding tube in patients with BRAF-mutated thyroid cancer: a case series and review of literature.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Stability study of concentrate-solvent mixture & infusion solutions of Jevtana® cabazitaxel for extended multi-dosing.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Image-based analysis of skeletal muscle mass predicts cisplatin dose-limiting toxicity in patients with locally advanced head and neck cancer.

Cancer chemotherapy and pharmacology

Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies.

Frontiers in pharmacology

Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice.

11-06-2022

Journal of pharmaceutical and biomedical analysis

A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS.

05-06-2022

British journal of cancer

Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity.

01-06-2022

Journal of cachexia, sarcopenia and muscle

The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients.

01-06-2022

Scientific reports

Deep learning body-composition analysis of clinically acquired CT-scans estimates creatinine excretion with high accuracy in patients and healthy individuals.

30-05-2022

Cancer chemotherapy and pharmacology

Is age just a number? A population pharmacokinetic study of gemcitabine.

01-05-2022

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Optimized sample pre-treatment procedure for the simultaneous UPLC-MS/MS quantification of ipilimumab, nivolumab, and pembrolizumab in human serum.

30-04-2022

Blood advances

Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia.

12-04-2022

Clinical pharmacokinetics

Correction to: Unbound Plasma, Total Plasma and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.

01-04-2022

Pharmaceutical research

Ritonavir-Boosted Exposure of Kinase Inhibitors: an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib.

01-04-2022

Clinical cancer research : an official journal of the American Association for Cancer Research

Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment.

01-04-2022

The Lancet. Oncology

Toxicity and efficacy of chronomodulated chemotherapy: a systematic review.

01-03-2022

European journal of cancer (Oxford, England : 1990)

Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.

01-03-2022

Clinical and experimental rheumatology

Is there a potential for therapeutic drug monitoring of subcutaneously administered tocilizumab in patients with rheumatoid arthritis in daily practice?

01-03-2022

Journal of chromatography. A

Middle-up quantification of therapeutic monoclonal antibodies in human plasma with two dimensional liquid chromatography high resolution mass spectrometry: Adalimumab as a proof of principle.

22-02-2022

Journal of pharmaceutical sciences

Population Pharmacokinetic Modelling to Support the Evaluation of Preclinical Pharmacokinetic Experiments with Lorlatinib.

Clinical pharmacokinetics

Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.

British journal of clinical pharmacology

Hyperhydration with cisplatin does not influence pemetrexed exposure.

Clinical pharmacology and therapeutics

Effects of the Moderate CYP3A4 Inhibitor Erythromycin on the Pharmacokinetics of Palbociclib: A Randomized Crossover Trial in Patients With Breast Cancer.

Cancers

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy in Children with Cancer: A Systematic Review and Meta-Analysis.

26-01-2022

BMC cancer

The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials.

25-01-2022

BMJ open

Plasma concentration guided dosing of drugs used for the treatment of childhood leukaemias: protocol for a systematic review.

03-01-2022

Best practice & research. Clinical obstetrics & gynaecology

Translational and pharmacological principles of hyperthermic intraperitoneal chemotherapy for ovarian cancer.

European journal of cancer (Oxford, England : 1990)

The association of cisplatin pharmacokinetics and skeletal muscle mass in patients with head and neck cancer: The prospective PLATISMA study.

Drugs

Optimized Dosing: The Next Step in Precision Medicine in Non-Small-Cell Lung Cancer.

Targeted oncology

Representativeness of Phase III Trial for Osimertinib in Pretreated Advanced EGFR-Mutated Non-small-cell Lung Cancer Patients and Treatment Outcomes in Clinical Practice.