Publications

Cell reports

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

19-02-2019

The Journal of biological chemistry

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

14-12-2018

Life science alliance

Direct binding of Cdt2 to PCNA is important for targeting the CRL4^Cdt2 E3 ligase activity to Cdt1.

01-12-2018

Acta crystallographica. Section F, Structural biology communications

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

01-11-2018

The Journal of biological chemistry

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

14-09-2018

IUCrJ

Homology-based loop modeling yields more complete crystallographic protein structures.

01-09-2018

Nature cell biology

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

01-07-2018

Protein science : a publication of the Protein Society

Homology-based hydrogen bond information improves crystallographic structures in the PDB.

01-03-2018

The international journal of biochemistry & cell biology

Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

01-01-2018

Science (New York, N.Y.)

Vasohibins encode tubulin detyrosinating activity.

15-12-2017

The Journal of biological chemistry

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

01-09-2017

eLife

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

29-08-2017

Journal of medicinal chemistry

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

09-03-2017

Journal of medicinal chemistry

Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.

26-01-2017

Nature

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

19-01-2017

Proteins

Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.

01-12-2016

Cancer cell

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

10-10-2016

Journal of structural biology

Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

01-08-2016

Current opinion in structural biology

Recombinant cloning strategies for protein expression.

01-06-2016

Current opinion in structural biology

Editorial overview: New constructs and expression of proteins.

01-06-2016

Methods in molecular biology (Clifton, N.J.)

Data Mining of Macromolecular Structures.

27-04-2016

Nature communications

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

14-04-2016

Acta crystallographica. Section D, Biological crystallography

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

01-11-2015

Science (New York, N.Y.)

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

12-06-2015

Proceedings of the National Academy of Sciences of the United States of America

The first step of peptide selection in antigen presentation by MHC class I molecules.

03-02-2015

IUCrJ

The PDB_REDO server for macromolecular structure model optimization.

01-07-2014

Journal of lipid research

Autotaxin: structure-function and signaling.

01-06-2014

Acta crystallographica. Section D, Biological crystallography

Timely deposition of macromolecular structures is necessary for peer review.

01-12-2013

The Journal of biological chemistry

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.

01-11-2013

The Journal of biological chemistry

The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.

04-01-2013

Advances in biological regulation

Structure-function relationships of autotaxin, a secreted lysophospholipase D.

01-01-2013

Cell

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

31-08-2012

Sub-cellular biochemistry

Cdt1 and geminin in DNA replication initiation.

25-08-2012

Journal of the American Chemical Society

Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding.

15-08-2012

Acta crystallographica. Section D, Biological crystallography

PDB_REDO: constructive validation, more than just looking for errors.

01-04-2012

Bioinformatics (Oxford, England)

Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank.

15-12-2011

Molecular cell

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

07-10-2011

Nature reviews. Molecular cell biology

Insights into autotaxin: how to produce and present a lipid mediator.

14-09-2011

Journal of structural biology

Investigating a macromolecular complex: the toolkit of methods.

01-08-2011

Journal of structural biology

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

01-08-2011

Journal of medicinal chemistry

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

14-07-2011

Nucleic acids research

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

01-07-2011

Nature structural & molecular biology

Structural basis of substrate discrimination and integrin binding by autotaxin.

01-02-2011

Acta crystallographica. Section F, Structural biology and crystallization communications

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein.

01-09-2010

Nucleic acids research

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

01-07-2010

Proteins

Structure of human CLIC3 at 2 A resolution.

01-05-2010

Proceedings of the National Academy of Sciences of the United States of America

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

24-11-2009

Journal of the American Chemical Society

UV-induced ligand exchange in MHC class I protein crystals.

02-09-2009

Journal of the American Chemical Society

Class I major histocompatibility complexes loaded by a periodate trigger.

02-09-2009

Nucleic acids research

ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments.

01-07-2009

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1.

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

Homology-based loop modeling yields more complete crystallographic protein structures.

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Homology-based hydrogen bond information improves crystallographic structures in the PDB.

Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

Vasohibins encode tubulin detyrosinating activity.

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

Recombinant cloning strategies for protein expression.

Editorial overview: New constructs and expression of proteins.

Data Mining of Macromolecular Structures.

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

The first step of peptide selection in antigen presentation by MHC class I molecules.

The PDB_REDO server for macromolecular structure model optimization.

Autotaxin: structure-function and signaling.

Timely deposition of macromolecular structures is necessary for peer review.

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.

The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.

Structure-function relationships of autotaxin, a secreted lysophospholipase D.

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

Cdt1 and geminin in DNA replication initiation.

Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding.

PDB_REDO: constructive validation, more than just looking for errors.

Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank.

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

Insights into autotaxin: how to produce and present a lipid mediator.

Investigating a macromolecular complex: the toolkit of methods.

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

Structural basis of substrate discrimination and integrin binding by autotaxin.

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein.

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

Structure of human CLIC3 at 2 A resolution.

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

UV-induced ligand exchange in MHC class I protein crystals.

Class I major histocompatibility complexes loaded by a periodate trigger.

ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments.

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Direct binding of Cdt2 to PCNA is important for targeting the CRL4^Cdt2 E3 ligase activity to Cdt1.