Publications

The Journal of biological chemistry

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

01-09-2017

eLife

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

29-08-2017

Journal of medicinal chemistry

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

09-03-2017

Journal of medicinal chemistry

Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.

26-01-2017

Nature

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

19-01-2017

Proteins

Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.

01-12-2016

Cancer cell

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

10-10-2016

Journal of structural biology

Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

01-08-2016

Current opinion in structural biology

Recombinant cloning strategies for protein expression.

01-06-2016

Current opinion in structural biology

Editorial overview: New constructs and expression of proteins.

01-06-2016

Methods in molecular biology (Clifton, N.J.)

Data Mining of Macromolecular Structures.

27-04-2016

Nature communications

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

14-04-2016

Acta crystallographica. Section D, Biological crystallography

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.

01-11-2015

Science (New York, N.Y.)

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

12-06-2015

Proceedings of the National Academy of Sciences of the United States of America

The first step of peptide selection in antigen presentation by MHC class I molecules.

03-02-2015

IUCrJ

The PDB_REDO server for macromolecular structure model optimization.

01-07-2014

Journal of lipid research

Autotaxin: structure-function and signaling.

01-06-2014

Acta crystallographica. Section D, Biological crystallography

Timely deposition of macromolecular structures is necessary for peer review.

01-12-2013

The Journal of biological chemistry

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.

01-11-2013

The Journal of biological chemistry

The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.

04-01-2013

Advances in biological regulation

Structure-function relationships of autotaxin, a secreted lysophospholipase D.

01-01-2013

Cell

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

31-08-2012

Sub-cellular biochemistry

Cdt1 and geminin in DNA replication initiation.

25-08-2012

Journal of the American Chemical Society

Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding.

15-08-2012

Acta crystallographica. Section D, Biological crystallography

PDB_REDO: constructive validation, more than just looking for errors.

01-04-2012

Bioinformatics (Oxford, England)

Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank.

15-12-2011

Molecular cell

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

07-10-2011

Nature reviews. Molecular cell biology

Insights into autotaxin: how to produce and present a lipid mediator.

14-09-2011

Journal of structural biology

Investigating a macromolecular complex: the toolkit of methods.

01-08-2011

Journal of structural biology

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

01-08-2011

Journal of medicinal chemistry

Structure-based design of novel boronic acid-based inhibitors of autotaxin.

14-07-2011

Nucleic acids research

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

01-07-2011

Nature structural & molecular biology

Structural basis of substrate discrimination and integrin binding by autotaxin.

01-02-2011

Acta crystallographica. Section F, Structural biology and crystallization communications

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein.

01-09-2010

Nucleic acids research

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence.

01-07-2010

Proteins

Structure of human CLIC3 at 2 A resolution.

01-05-2010

Proceedings of the National Academy of Sciences of the United States of America

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.

24-11-2009

Journal of the American Chemical Society

UV-induced ligand exchange in MHC class I protein crystals.

02-09-2009

Journal of the American Chemical Society

Class I major histocompatibility complexes loaded by a periodate trigger.

02-09-2009

Nucleic acids research

ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments.

01-07-2009

Journal of medicinal chemistry

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

23-04-2009

Proteins

Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease.

01-03-2009

Structure (London, England : 1993)

"Conditional Restraints": Restraining the Free Atoms in ARP/wARP.

13-02-2009

Methods in molecular biology (Clifton, N.J.)

Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview.

11-06-2008

Acta crystallographica. Section D, Biological crystallography

A knowledge-driven approach for crystallographic protein model completion.

01-04-2008

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement: the next generation.

01-01-2008

Cell

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

28-12-2007

Nucleic acids research

Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease.

13-07-2007

Nucleic acids research

The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase.

29-03-2007

The EMBO journal

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

07-06-2006