Publications

Molecular cell

Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.

07-12-2023

EMBO reports

DOT1L regulates chromatin reorganization and gene expression during sperm differentiation.

05-06-2023

Nature structural & molecular biology

Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting.

01-05-2023

Frontiers in genetics

DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro.

26-11-2022

Cell reports

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

22-11-2022

Journal of cell science

The histone methyltransferase SETD2 negatively regulates cell size.

01-10-2022

Cellular and molecular life sciences : CMLS

SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.

06-06-2022

Methods in molecular biology (Clifton, N.J.)

Epi-Decoder: Decoding the Local Proteome of a Genomic Locus by Massive Parallel Chromatin Immunoprecipitation Combined with DNA-Barcode Sequencing.

02-02-2022

Cellular and molecular life sciences : CMLS

Signals for antigen-independent differentiation of memory CD8⁺ T cells.

01-10-2021

Scientific reports

Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies.

17-06-2021

EMBO reports

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

03-02-2021

Epigenetics

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells.

01-09-2020

Proceedings of the National Academy of Sciences of the United States of America

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

25-08-2020

Journal of cell science

A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in S. cerevisiae.

22-05-2020

Genome research

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.

01-04-2020

Frontiers in chemistry

Strategy for Development of Site-Specific Ubiquitin Antibodies.

11-03-2020

Nature communications

CD4⁺ T cell help creates memory CD8⁺ T cells with innate and help-independent recall capacities.

04-12-2019

Melanoma research

A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma.

01-12-2019

Methods in molecular biology (Clifton, N.J.)

Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq.

12-10-2019

The EMBO journal

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

15-07-2019

Nucleic acids research

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.

30-11-2018

PLoS biology

Decoding the chromatin proteome of a single genomic locus by DNA sequencing.

01-07-2018

Toxicology in vitro : an international journal published in association with BIBRA

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.

01-03-2018

PloS one

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae.

16-03-2017

eLife

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1.

06-12-2016

Chromosoma

The upstreams and downstreams of H3K79 methylation by DOT1L.

01-09-2016

Scientific reports

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

12-05-2015

Molecular cell

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

22-01-2015

Journal of cell science

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging.

01-01-2015

Leukemia

The emerging roles of DOT1L in leukemia and normal development.

01-11-2014

EMBO reports

Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.

01-10-2014

Cell reports

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

26-12-2013

G3 (Bethesda, Md.)

Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae.

07-08-2013

Molecular cell

A network model of the molecular organization of chromatin in Drosophila.

21-02-2013

Proceedings of the National Academy of Sciences of the United States of America

Spatiotemporal analysis of organelle and macromolecular complex inheritance.

02-01-2013

PLoS genetics

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.

01-10-2011

Epigenetics & chromatin

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.

03-02-2011

Chembiochem : a European journal of chemical biology

A modified epigenetics toolbox to study histone modifications on the nucleosome core.

24-01-2011

Journal of cell science

Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei.

01-12-2010

Proceedings of the National Academy of Sciences of the United States of America

Recombination-induced tag exchange to track old and new proteins.

05-01-2010

Nucleic acids research

Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome.

01-11-2009

BMC molecular biology

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.

28-07-2009

Chembiochem : a European journal of chemical biology

Chemical biology approaches to probe the proteome.

15-12-2008

Molecular and cellular biology

Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.

01-06-2008

Nature structural & molecular biology

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states.

01-06-2008

Genome biology

Histone modifications: from genome-wide maps to functional insights.

18-06-2005

Molecular and biochemical parasitology

Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

01-07-2000

The EMBO journal

The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.

15-11-1999

Molecular and cellular biology

Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

01-10-1998

Molecular and biochemical parasitology

The modified DNA base beta-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei.

01-07-1998