Publications

Molecular oncology

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma.

30-07-2025

Trends in cancer

Prospects for understanding and exploiting the consequences of hyperactivation lethality.

01-07-2025

Proceedings of the National Academy of Sciences of the United States of America

Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability.

20-05-2025

Cell death and differentiation

Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state.

01-05-2025

The Journal of pathology

Afadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage.

01-05-2025

Gut

Perturbation of mRNA splicing in liver cancer: insights, opportunities and challenges.

07-04-2025

Signal transduction and targeted therapy

Hepatocellular carcinoma: signaling pathways and therapeutic advances.

07-02-2025

Proceedings of the National Academy of Sciences of the United States of America

Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.

07-01-2025

Cancer cell

Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy.

09-12-2024

Signal transduction and targeted therapy

Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial.

09-12-2024

Nature reviews. Cancer

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.

01-10-2024

Molecular oncology

A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm.

01-10-2024

Clinical cancer research : an official journal of the American Association for Cancer Research

A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in BRAFV600-Mutated Melanoma.

01-08-2024

Cancer discovery

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy.

01-07-2024

Cancer cell

The case for therapeutic overactivation of oncogenic signaling as a potential cancer treatment strategy.

10-06-2024

Cell reports. Medicine

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.

19-03-2024

Cancer cell

Precision treatment in advanced hepatocellular carcinoma.

12-02-2024

Cell research

LICOB: a powerful organoid platform for drug discovery.

01-01-2024

Molecular oncology

Molecular Oncology and the EACR: new partners in communicating and supporting cancer research.

01-06-2023

Molecular oncology

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.

01-06-2023

Clinical and translational medicine

Drug-drug synthetic lethality to combat cancer: From bench to bedside.

01-05-2023

Angiogenesis

Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.

01-05-2023

Nature reviews. Gastroenterology & hepatology

Evolving therapeutic landscape of advanced hepatocellular carcinoma.

01-04-2023

Molecular oncology

More may not be better: reconsidering early clinical trial design in the era of targeted cancer therapeutics.

01-03-2023

Nature cancer

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF^V600E colorectal tumors.

01-02-2023

Cell reports. Medicine

Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

15-11-2022

Nature cancer

cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.

01-11-2022

PloS one

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

07-09-2022

Life science alliance

Genetic and compound screens uncover factors modulating cancer cell response to indisulam.

01-09-2022

Cell discovery

EGFR blockade confers sensitivity to cabozantinib in hepatocellular carcinoma.

23-08-2022

iScience

Identifying mutant-specific multi-drug combinations using comparative network reconstruction.

19-08-2022

Nature communications

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II.

24-06-2022

NPJ breast cancer

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant.

08-06-2022

Cell genomics

A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer.

09-02-2022

Nature reviews. Gastroenterology & hepatology

Exploring liver cancer biology through functional genetic screens.

01-10-2021

Molecular cancer research : MCR

Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen.

01-10-2021

Molecular oncology

Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention.

01-08-2021

Cell reports

The Cancer SENESCopedia: A delineation of cancer cell senescence.

27-07-2021

Nature cell biology

Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.

01-07-2021

Nature cell biology

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.

01-06-2021

The oncologist

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

01-04-2021

Cancers

Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells.

05-03-2021

Genome medicine

Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.

10-02-2021

British journal of cancer

Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.

01-01-2021

Cancer research

A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer.

15-11-2020

International journal of cancer

Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis.

15-10-2020

Molecular oncology

Towards a cancer mission in Horizon Europe: recommendations.

01-08-2020

Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

01-04-2020

Future oncology (London, England)

Vorinostat in patients with resistant BRAF^V600E mutated advanced melanoma: a proof of concept study.

01-04-2020