Publications

Science advances

Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.

12-12-2025

Neoplasia (New York, N.Y.)

Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.

01-12-2025

Trends in immunology

Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma.

07-11-2025

Blood

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma.

17-04-2025

Future oncology (London, England)

Advancing real-world research in thoracic malignancies: learnings from the international I-O Optimise initiative.

01-03-2025

Genome biology

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.

31-12-2024

Nucleic acids research

ADARp150 counteracts whole genome duplication.

23-09-2024

Oncogenesis

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.

11-07-2024

PNAS nexus

Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.

01-07-2024

Cellular & molecular immunology

CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

01-04-2024

International journal of molecular sciences

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

05-07-2023

Nature communications

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

17-04-2023

Frontiers in immunology

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

27-01-2023

Proceedings of the National Academy of Sciences of the United States of America

Mammalian life depends on two distinct pathways of DNA damage tolerance.

24-01-2023

International journal of molecular sciences

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model.

02-01-2023

Frontiers in genetics

DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro.

26-11-2022

Cell reports

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

22-11-2022

Nucleic acids research

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.

22-07-2022

Cell reports

Tumor-educated T_regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.

01-03-2022

eLife

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.

08-02-2022

Frontiers in immunology

Tandem Substitutions in Somatic Hypermutation.

25-01-2022

Cellular and molecular life sciences : CMLS

Signals for antigen-independent differentiation of memory CD8⁺ T cells.

01-10-2021

Frontiers in pharmacology

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

09-03-2021

EMBO reports

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

03-02-2021

Cell reports

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

29-12-2020