Publications

Proceedings of the National Academy of Sciences of the United States of America

Enterovirus D68 receptor requirements unveiled by haploid genetics.

02-02-2016

Journal of virology

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

01-02-2016

eLife

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.

23-12-2015

Chemistry & biology

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

17-12-2015

Nature communications

A generic strategy for CRISPR-Cas9-mediated gene tagging.

17-12-2015

The EMBO journal

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

14-12-2015

Science (New York, N.Y.)

Gene essentiality and synthetic lethality in haploid human cells.

27-11-2015

Cancer research

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

01-10-2015

eLife

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

01-09-2015

Trends in microbiology

Emerging intracellular receptors for hemorrhagic fever viruses.

01-07-2015

mBio

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.

30-06-2015

Science (New York, N.Y.)

GENE REGULATION. A HUSH for transgene expression.

26-06-2015

mBio

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

26-05-2015

Nature communications

Dissecting the role of aberrant DNA methylation in human leukaemia.

22-05-2015

Genome research

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

01-12-2014

Nature chemical biology

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

01-09-2014

The Journal of biological chemistry

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

29-08-2014

Cancer research

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

15-07-2014

Science (New York, N.Y.)

Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

27-06-2014

Science (New York, N.Y.)

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

06-06-2014

Cell reports

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

10-04-2014

Journal of cell science

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.

01-08-2013

Science (New York, N.Y.)

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

26-04-2013

The Journal of biological chemistry

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

15-03-2013

Molecular cancer research : MCR

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

01-09-2008

Nature methods

shRNA libraries and their use in cancer genetics.

01-09-2006

The British journal of dermatology

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

01-07-2006

Nature chemical biology

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

01-04-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

Methods in enzymology

Functional annotation of deubiquitinating enzymes using RNA interference.

09-11-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Molecular cell

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

04-02-2005

Nature

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

25-03-2004

Nature reviews. Cancer

New tools for functional mammalian cancer genetics.

01-10-2003

Nature

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

14-08-2003

The EMBO journal

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

16-06-2003

Cancer cell

Stable suppression of tumorigenicity by virus-mediated RNA interference.

01-09-2002

Science (New York, N.Y.)

A system for stable expression of short interfering RNAs in mammalian cells.

19-04-2002

Genes & development

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

15-03-2002

The Journal of biological chemistry

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

22-02-2002

Nature cell biology

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

01-02-2002

Enterovirus D68 receptor requirements unveiled by haploid genetics.

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

A generic strategy for CRISPR-Cas9-mediated gene tagging.

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

Gene essentiality and synthetic lethality in haploid human cells.

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Emerging intracellular receptors for hemorrhagic fever viruses.

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.

GENE REGULATION. A HUSH for transgene expression.

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

Dissecting the role of aberrant DNA methylation in human leukaemia.

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

Virus entry. Lassa virus entry requires a trigger-induced receptor switch.

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

shRNA libraries and their use in cancer genetics.

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

A genomic and functional inventory of deubiquitinating enzymes.

Functional annotation of deubiquitinating enzymes using RNA interference.

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

New tools for functional mammalian cancer genetics.

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

Stable suppression of tumorigenicity by virus-mediated RNA interference.

A system for stable expression of short interfering RNAs in mammalian cells.

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.

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