Publications

Nature communications

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.

24-11-2025

Nature

NASP modulates histone turnover to drive PARP inhibitor resistance.

01-09-2025

Nature

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

01-09-2025

Molecular cell

Condensin II activation by M18BP1.

17-07-2025

Science (New York, N.Y.)

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression.

03-07-2025

Nature

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease.

01-06-2025

Cell reports

SRBD1, a highly conserved gene required for chromosome individualization.

22-04-2025

The EMBO journal

Chromatin protein complexes involved in gene repression in lamina-associated domains.

01-11-2024

Nature structural & molecular biology

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

01-09-2024

FEBS letters

Decoding microtubule detyrosination: enzyme families, structures, and functional implications.

01-06-2024

Science (New York, N.Y.)

DNA damage induces p53-independent apoptosis through ribosome stalling.

17-05-2024

Cancer cell

CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.

09-10-2023

Nature

Identification of an alternative triglyceride biosynthesis pathway.

01-09-2023

Molecular oncology

MND1 enables homologous recombination in somatic cells primarily outside the context of replication.

01-07-2023

Science advances

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.

02-06-2023

Journal of visualized experiments : JoVE

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy.

03-03-2023

Science (New York, N.Y.)

Actin maturation requires the ACTMAP/C19orf54 protease.

30-09-2022

The EMBO journal

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.

01-09-2022

Nature structural & molecular biology

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.

01-06-2022

Science (New York, N.Y.)

Posttranslational modification of microtubules by the MATCAP detyrosinase.

20-05-2022

Nature communications

A Mediator-cohesin axis controls heterochromatin domain formation.

08-02-2022

Immunity

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

12-01-2021

Proceedings of the National Academy of Sciences of the United States of America

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

05-01-2021

Science signaling

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

15-09-2020

Cell reports

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

25-08-2020

Science translational medicine

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

20-05-2020

Nature communications

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.

28-02-2020

Nature structural & molecular biology

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

01-07-2019

Journal of virology

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

01-07-2019

Nature medicine

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

01-04-2019

PloS one

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

13-02-2019

Nature communications

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

09-01-2019

Trends in cell biology

The Tubulin Detyrosination Cycle: Function and Enzymes.

01-01-2019

Science (New York, N.Y.)

LZTR1 is a regulator of RAS ubiquitination and signaling.

07-12-2018

Cancer research

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

01-12-2018

Nature

Protocadherin-1 is essential for cell entry by New World hantaviruses.

01-11-2018

Current biology : CB

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

10-09-2018

Journal of cell science

Viral escape from endosomes and host detection at a glance.

03-08-2018

Molecular oncology

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

01-06-2018

Cell host & microbe

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

09-05-2018

Cell reports

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

06-02-2018

Science (New York, N.Y.)

Vasohibins encode tubulin detyrosinating activity.

15-12-2017

Cell host & microbe

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

08-11-2017

Arteriosclerosis, thrombosis, and vascular biology

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

01-11-2017

Cell host & microbe

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

11-10-2017

Nature

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

07-09-2017

Nature

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

08-06-2017

Cell

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

04-05-2017

Nature

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

19-01-2017

mSphere

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

16-06-2016

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.

NASP modulates histone turnover to drive PARP inhibitor resistance.

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Condensin II activation by M18BP1.

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression.

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease.

SRBD1, a highly conserved gene required for chromosome individualization.

Chromatin protein complexes involved in gene repression in lamina-associated domains.

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

Decoding microtubule detyrosination: enzyme families, structures, and functional implications.

DNA damage induces p53-independent apoptosis through ribosome stalling.

CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.

Identification of an alternative triglyceride biosynthesis pathway.

MND1 enables homologous recombination in somatic cells primarily outside the context of replication.

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy.

Actin maturation requires the ACTMAP/C19orf54 protease.

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.

Posttranslational modification of microtubules by the MATCAP detyrosinase.

A Mediator-cohesin axis controls heterochromatin domain formation.

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

The Tubulin Detyrosination Cycle: Function and Enzymes.

LZTR1 is a regulator of RAS ubiquitination and signaling.

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

Viral escape from endosomes and host detection at a glance.

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

Vasohibins encode tubulin detyrosinating activity.

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

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