Publications

Nature structural & molecular biology

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

22-04-2024

Cancer cell

CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1.

09-10-2023

Nature

Identification of an alternative triglyceride biosynthesis pathway.

01-09-2023

Molecular oncology

MND1 enables homologous recombination in somatic cells primarily outside the context of replication.

01-07-2023

Science advances

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.

02-06-2023

Journal of visualized experiments : JoVE

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy.

03-03-2023

Science (New York, N.Y.)

Actin maturation requires the ACTMAP/C19orf54 protease.

30-09-2022

The EMBO journal

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.

01-09-2022

Nature structural & molecular biology

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism.

01-06-2022

Science (New York, N.Y.)

Posttranslational modification of microtubules by the MATCAP detyrosinase.

20-05-2022

Nature communications

A Mediator-cohesin axis controls heterochromatin domain formation.

08-02-2022

Immunity

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

12-01-2021

Proceedings of the National Academy of Sciences of the United States of America

E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

05-01-2021

Science signaling

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

15-09-2020

Cell reports

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.

25-08-2020

Science translational medicine

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

20-05-2020

Nature communications

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.

28-02-2020

Nature structural & molecular biology

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

01-07-2019

Journal of virology

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

01-07-2019

Nature medicine

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

01-04-2019

PloS one

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing.

13-02-2019

Nature communications

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity.

09-01-2019

Trends in cell biology

The Tubulin Detyrosination Cycle: Function and Enzymes.

01-01-2019

Science (New York, N.Y.)

LZTR1 is a regulator of RAS ubiquitination and signaling.

07-12-2018

Cancer research

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

01-12-2018

Nature

Protocadherin-1 is essential for cell entry by New World hantaviruses.

01-11-2018

Current biology : CB

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

10-09-2018

Journal of cell science

Viral escape from endosomes and host detection at a glance.

03-08-2018

Molecular oncology

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

01-06-2018

Cell host & microbe

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

09-05-2018

Cell reports

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

06-02-2018

Science (New York, N.Y.)

Vasohibins encode tubulin detyrosinating activity.

15-12-2017

Cell host & microbe

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

08-11-2017

Arteriosclerosis, thrombosis, and vascular biology

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

01-11-2017

Cell host & microbe

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

11-10-2017

Nature

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

07-09-2017

Nature

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling.

08-06-2017

Cell

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.

04-05-2017

Nature

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

19-01-2017

mSphere

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

16-06-2016

Proceedings of the National Academy of Sciences of the United States of America

Enterovirus D68 receptor requirements unveiled by haploid genetics.

02-02-2016

Journal of virology

A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection.

01-02-2016

eLife

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.

23-12-2015

Chemistry & biology

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

17-12-2015

Nature communications

A generic strategy for CRISPR-Cas9-mediated gene tagging.

17-12-2015

The EMBO journal

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

14-12-2015

Science (New York, N.Y.)

Gene essentiality and synthetic lethality in haploid human cells.

27-11-2015

Cancer research

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.

01-10-2015

eLife

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

01-09-2015

Trends in microbiology

Emerging intracellular receptors for hemorrhagic fever viruses.

01-07-2015