B Cast Afbeelding PRS

Common genetic variants influence the risk of new breast tumor after breast cancer


The odds of developing a tumor in the second breast after breast cancer can be more accurately predicted through a risk score based on hundreds of common genetic variants, researchers of the Netherlands Cancer Institute show in their publication in the American Journal of Human Genetics. The researchers looked into the predictive value of the previously developed Polygenic Risk Score (PRS) in over 56,000 breast cancer patients.

Approximately 4% of breast cancer patients develop a second tumor in the other breast within 10 years after their first diagnosis. Researchers are eager to find the odds for each individual patient. "Patient with high risk scores can opt for a preventative mastectomy on the healthy breast, or come in for additional screenings," researcher Iris Kramer explains. "Patients with lower risk scores can feel more at ease. We can't underestimate how meaningful that can be."

This site uses cookies

This website uses cookies to ensure you get the best experience on our website.