“During my Master’s studies in Biomolecular Sciences, I went on an excursion to the Biochemistry department at the Netherlands Cancer Institute. I loved seeing the work that they did in the lab, so I quickly sent an email to find out more about doing a potential internship. One thing led to another, and I am now pursuing my PhD at the NKI, studying a protein called USP1. This protein plays a role in DNA replication and helps ensure that the process does not come to a complete halt with every minor error. It is remarkable how much research can focus on a single protein.
I needed large amounts of this protein so I could study it under an electron microscope. Artificial intelligence allows us to create three-dimensional images of this tiny protein. The process starts with an abstract, rounded shape, and the resolution improves with each step. This type of image provides insight into how this protein functions and how drugs, for example, might bind to it. I also enjoy experiments in my free time: from fermented vegetables and sourdough bread to creating my own soft drinks, I love trying out new things.”
Niels Keijzer will defend his PhD thesis on February 3. Good luck Niels!
Research at the Netherlands Cancer Institute is financially supported by KWF Dutch Cancer Society and the AVL Foundation.
Promotor(s)
Titia Sixma
Copromotor(s)
Anastassis Perrakis