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We use a combination of structural biology, biophysics and biochemistry to quantitatively analyze molecular mechanisms in cells. Our lab is interested in DNA regulation by ubiquitin and DNA mismatch repair. Crystal structures from the lab provided the first structural insight in ligand binding for pentameric ion channels such as the nicotinic receptors, and insight in the initiation of DNA mismatch repair. Our interest in ubiquitin conjugation led among others to identification of a new chromatin mark in the DNA damage response, novel insight in the allosteric regulation of DUBs.
Titia Sixma received her PhD in Groningen with Wim Hol and did her post-doc with Paul Sigler at Yale. She is head of the division of Biochemistry at the Netherlands Cancer Institute and ‘bijzonder hoogleraar’ at ErasmusMC (affiliated Professor). She is member of EMBO (2004), Academia Europaea (2008) and the Netherlands Academy KNAW. She received the NVBMB prize, an ERC advanced grant, several TOP research grants and is a member of the Oncode Institute.