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Oncogenomics: Wilbert Zwart

Research interest: Hormone-Associated Cancers

As a lab, we position ourselves as a multidisciplinary translational endocrinology group. As such, we operate at the intersection of genomics, pathology, cell biology and molecular pathology. I strongly believe that combining specialities from different research fields is key for innovative translational science in cancer research. The hormone-related mechanisms in transcriptional regulation of breast cancer, endometrial cancer and prostate cancer are tightly linked, creating many opportunities for synergy between the research lines in the lab. The central theme of our research projects revolves around personalized cancer treatment, where we aim to identify novel biomarkers and to unravel the underlying biological mechanisms. 

 

Co-workers

Joosten, Stacey

Stacey Joosten, MSc

Ph.D. student

Experience

In 2012, I obtained a bachelor degree in biomedical sciences at the VU University of Amsterdam. My bachelor internship at the Hubrecht Institute inspired me to specialize in oncology. I enrolled in the master Oncology at the VU University Medical Centre, for which I performed two additional internships at the Cancer Centre Amsterdam and the NKI-AVL. I also pursued a degree in healthcare policy.

Recently, I joined the lab of Wilbert Zwart as a PhD student. In collaboration with the group of Sabine Linn, we aim to develop a predictive profile for endocrine treatment in breast cancer.  

 

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Kneppers

Jeroen Kneppers

Ph.D. student

Experience

As a 2016 MSc Molecular Life Sciences graduate from Wageningen University (WUR), I have investigated gene editing tools such as CRISPR-Cas12a in the Zhang lab at the Broad Institute, Cambridge, USA. My current technical expertise are in Molecular Biology, Next Generation Sequencing (NGS) and CRISPR. My research project at the NKI focuses on interactions of nuclear receptors in the prostate cancer microenvironment. Eventually, it is my hope that our findings results in the discovery of better prognostic biomarkers, which will enable improved personalized treatment of patients.

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Linder, Simon

Simon Linder

Ph.D. student

Experience

I obtained my Bachelor's as well as my Master's degree in Biomolecular Engineering from the Technical University of Darmstadt, Germany. Within my Master's studies I have performed an internship at the Netherlands Cancer Institute in the lab of René Medema. In June 2017, I joined the groups of Wilbert Zwart and André Bergman as a Ph.D. student. Here, my project focuses on genome-wide profiling of Androgen Receptor action in clinical specimens, in search of biomarkers for prognostication and treatment selection in prostate cancer.

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Louhanepassy

Rebecca Louhanepessy

Ph.D. student

Experience

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Mayayo Peralta, Isabel

Isabel Mayayo Peralta

Ph.D. student

Experience

I graduated in Medical Biochemistry from the University of Navarra (Spain). Next, I obtained my Master's degree in Medical Biology from the University of Amsterdam. Being interested in oncological research, I joined the lab of Dr Wilbert Zwart as a PhD student in December 2016.

In my project, I will focus on progressive metastatic breast cancer. With this project we aim to gain new insights into the proteomic, genomic and epigenetic landscape of the metastatic disease in relation to personalised therapeutic approaches.

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Prekovic, Stefan

Stefan Prekovic

Postdoctoral Fellow

Experience

I obtained my master's degree in molecular genetics at the Centre for Human Molecular Genetics, University of Belgrade (Serbia). Following that, I moved to the Faculty of Medicine, KU Leuven (Belgium), where I did my doctoral training. The focus of my research there was the molecular biology of the androgenreceptor and resistance to antiandrogens in prostate cancer. After graduating in June 2017, I moved to Amsterdam (Netherlands) and started work as a postdoctoral fellow in the laboratory of Wilbert Zwart. My current research focuses on nuclear receptor genomics in non-endocrine cancers.

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Schuurman

Karianne Schuurman

Analist

Experience

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Severson, Tesa

Tesa Severson

Postdoctoral Fellow

Experience

I received my doctoral degree from Utrecht University with a focus on characterizing molecular and genetic features of breast cancer to better identify subgroups for specific treatments. In order to study these features and integrate different data streams, I applied computational tools to analyze high-throughput genomics data from patient samples.

Currently, I am working in the lab of Wilbert Zwart emphasizing on prostate cancer using computation applications to interrogate the (epi-) genomic and transcriptomic landscape of prostate cancer patient samples.

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Zaalberg, Anniek

Anniek Zaalberg

Ph.D. student

Experience

I received my Master's degree in Oncology from the VUmc School of Medical Sciences, during which I performed two internships. One in the group of Heinz Jacobs at the NKI and one in the group of Shawn Demehri at Massachusetts General Hospital in Boston, where I investigated the mechanism of cancer development in the context of chronic inflammatory conditions.

In September 2017 I started as a PhD student in the group of Andre Bergman and Wilbert Zwart. My research project is mainly focused on defining the immune landscape in prostate cancer, the interaction of immune- and tumor cells and the effect of androgen signaling in immune cells.

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Zhu, Yanyun

Yanyun Zhu

Ph.D. student

Experience

I did my master in Wageningen University in food safety from 2013 to 2015. During my study, I followed my interest in oncology and did both of my master thesis and internship in this field, which studied the mutation of TP53 gene and the ERα positive breast cancer, in the toxicology department (the group of professor Ivonne Rietjens) of Wageningen University. 
Motivated by my strong interest in oncology, I decided to do a Ph.D. after I finished my master. In July 2016, I joined the groups of Wilbert Zwart and Andre Bergman as a Ph.D. student. My project focusses on biomarker discovery for response to Enzalutamide treatment in prostate cancer.

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Key publications View All Publications

  • Androgen receptor profiling predicts prostate cancer outcome

    (2015) EMBO Mol Med. Sep 27. pii: e201505424. doi: 10.15252/emmm.201505424. [Epub ahead of print]

    Stelloo S, Nevedomskaya E, van der Poel HG, de Jong J, van Leenders GJ, Jenster G, Wessels LF, Bergman AM, Zwart W.

    Link to PubMed
  • Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

    Nature Communications, 2017

    Severson T, Kim Y, Joosten S, Schuurman K, van der Groep P, Moelans C, ter Hoeve N, Manson Q, Martens J, van Deurzen C, Barbe E, Hedenfalk I, Bult P, Smit V, Linn SC, van Diest P, Wessels LFA, Zwart W.

    Link to PubMed
 
 

Recent publications View All Publications

  • Molecular underpinnings of enzalutamide resistance

    (2018) Endocr Relat Cancer

    Prekovic S, van den Broeck T, Linder S, van Royen ME, Houtsmuller AB, Handle F, Joniau S, Zwart W, Claessens F.

    Link to Pubmed
  • The Estrogen Receptor α-Cistrome Beyond Breast Cancer

    (2016) Mol Endocrinol. Oct;30(10):1046-1058.

    Droog M, Mensink M, Zwart W.

    Link to PubMed
 

Contact

  • Office manager

    Elise Marseille

  • E-mail

    e.marseille@nki.nl

  • Telephone Number

    +31 20 512 2015

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'Our goal is to fully personalize hormonal cancer treatment. To know which drug to give and to understand why it works. Support our research to help us achieve this goal.'

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