Immunofluorescence image of a murine recurrent brain tumor that relapsed after radiotherapy.
The abundant tumor-associated macrophages are depicted in red and white.

Leila Akkari

Macrophages in cancer

Interactions and heterotypic communications between tumors cells, the associated stroma and cells of the immune system profoundly influences various steps of cancer malignancy. We now appreciate that immune cells evolve in their composition and programming in a tissue, tumor and stage-dependent manner.

Our lab tackles these challenges by studying the profound complexity of immune cell regulation in the TME as it dynamically adapts within an evolving tumor, focusing on liver and brain cancer, to harness these cells in personalized anti-cancer treatments.

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