Accumulation of cancer-prone mismatch-repair-deficient intestinal crypts surrounded by wild-type crypts (brown staining) in a mouse model for Lynch syndrome

Hein Te Riele

Gene modification

Genomic instability is a hallmark of human cancer but how does genomic instability develop and impact the initiation and progression of cancer? We study two causes of genomic instability: (1) loss of DNA mismatch repair (MMR) and (2) defective G1/S control causing unscheduled S-phase entry and replication stress.

We develop novel gene modification tools to induce genomic instability in cell culture and mouse models and study whether this impacts tumor development and presents opportunities for therapeutic interventions.

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