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<p>Accumulation of cancer-prone mismatch-repair-deficient intestinal crypts surrounded by wild-type crypts (brown staining) in a mouse model for Lynch syndrome</p>

Hein Te Riele

Gene modification

Genomic instability is a hallmark of human cancer but how does genomic instability develop and impact the initiation and progression of cancer? We study two causes of genomic instability: (1) loss of DNA mismatch repair (MMR) and (2) defective G1/S control causing unscheduled S-phase entry and replication stress.

We develop novel gene modification tools to induce genomic instability in cell culture and mouse models and study whether this impacts tumor development and presents opportunities for therapeutic interventions.


News and stories

Te Riele Group - Promotion Tim Harmsen

Thesis defense Tim Harmsen

On October 27, 2020, Tim Harmsen defended his thesis “Gene editing à la carte: CRISPR/Cas-assisted single base-pair substitution”. Tim’s work provides novel insights into the mechanism of ssODN-mediated single base-pair substitution and presents protocols to improve its efficacy and precision.

Because of corona measures, Tim defended his thesis at the NKI-AVL, unique in the history of our institute!

 

Clinical research collaborations

Clinical research group Monique van Leerdam

 

Contact our group

NKI Placeholder Profiel
Karin van der Heijden Office Manager

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