Publications

Head & neck

Methotrexate plus or minus cetuximab as first-line treatment in a recurrent or metastatic (R/M) squamous cell carcinoma population of the head and neck (SCCHN), unfit for cisplatin combination treatment, a phase Ib-randomized phase II study Commence.

Journal of medical genetics

Three-step site-directed mutagenesis screen identifies pathogenic MLH1 variants associated with Lynch syndrome.

Nature cancer

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects.

Cancer chemotherapy and pharmacology

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The use of real-world evidence to audit normal tissue complication probability models for acute esophageal toxicity in non-small cell lung cancer patients.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Adherence to and satisfaction with low-intensity physical activity and supervised moderate-high intensity exercise during chemotherapy for breast cancer.

EJNMMI radiopharmacy and chemistry

Automated synthesis and quality control of [^99mTc]Tc-PSMA for radioguided surgery (in a [⁶⁸Ga]Ga-PSMA workflow).

Endoscopy

Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Quantitative imaging for radiotherapy purposes.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The prognostic value of volumetric changes of the primary tumor measured on Cone Beam-CT during radiotherapy for concurrent chemoradiation in NSCLC patients.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Differences in Patient-Reported Outcomes That Are Most Frequently Detected in Randomized Controlled Trials in Patients With Solid Tumors: A Pooled Analysis of 229 Trials.

Nature medicine

Caring for patients with cancer in the COVID-19 era.

Cancer immunology research

Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells.

Cancers

The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review.

30-04-2020

PloS one

A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition.

29-04-2020

Oncotarget

Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.

28-04-2020

Cellular and molecular gastroenterology and hepatology

Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.

25-04-2020

Cancers

Healthcare Costs of Metastatic Cutaneous Melanoma in the Era of Immunotherapeutic and Targeted Drugs.

18-04-2020

Clinical and experimental rheumatology

Acrocyanosis after neoadjuvant ipilimumab plus nivolumab: a case report.

18-04-2020

Journal of immunology (Baltimore, Md. : 1950)

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell-Dependent Route.

International journal of cancer

IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer.

NPJ precision oncology

Accurate surgical navigation with real-time tumor tracking in cancer surgery.

International journal of cancer

The prognostic value of the tumor-stroma ratio is most discriminative in patients with grade III or triple-negative breast cancer.

NPJ precision oncology

Accurate surgical navigation with real-time tumor tracking in cancer surgery.

08-04-2020

Nature communications

Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.

08-04-2020

Proceedings of the National Academy of Sciences of the United States of America

Targeting the cyclin-dependent kinase 5 in metastatic melanoma.

07-04-2020

Die Pharmazie

Development and validation of an LC-MS/MS method for the quantification of imatinib and imatinib-d8 in human plasma for the support of an absolute bioavailability microdose trial.

06-04-2020

Cell stem cell

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.

02-04-2020

Key Publication

JAMA oncology

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo: A Secondary Analysis of a Randomized Clinical Trial.

World journal of urology

Best practices in near-infrared fluorescence imaging with indocyanine green (NIRF/ICG)-guided robotic urologic surgery: a systematic review-based expert consensus.

International journal of cancer

Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes.

Journal of cancer survivorship : research and practice

Type of cancer treatment and cognitive symptoms in working cancer survivors: an 18-month follow-up study.

British journal of cancer

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer.

Nature medicine

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.

International journal of radiation oncology, biology, physics

Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial.

European urology oncology

Deferred Cytoreductive Nephrectomy Following Presurgical Vascular Endothelial Growth Factor Receptor-targeted Therapy in Patients with Primary Metastatic Clear Cell Renal Cell Carcinoma: A Pooled Analysis of Prospective Trial Data.

Journal of adolescent and young adult oncology

Exploring Communication About Intimacy and Sexuality: What Are the Preferences of Adolescents and Young Adults with Cancer and Their Health Care Professionals?

Molecular cancer research : MCR

Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity.

Breast cancer research and treatment

Breast cancer outcome in relation to bone mineral density and bisphosphonate use: a sub-study of the DATA trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Radiotherapy after primary CHEMotherapy (RAPCHEM): Practice variation in a Dutch registration study (BOOG 2010-03).

Genome research

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

New Approaches to SCLC Therapy: From the Laboratory to the Clinic.

Future oncology (London, England)

Vorinostat in patients with resistant BRAF^V600E mutated advanced melanoma: a proof of concept study.

Cancer discovery

Characteristics and Outcome of AKT1^E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry.

Journal of geriatric oncology

"I am busy surviving" - Views about physical exercise in older adults scheduled for colorectal cancer surgery.

Nature reviews. Cancer

CD8⁺ T cell states in human cancer: insights from single-cell analysis.

Clinical pharmacokinetics

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation.

International journal of radiation oncology, biology, physics

Preoperative Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Cancer Using ¹⁸F-FDG PET/CT and DW-MRI: A Prospective Multicenter Study.