Publications

High-throughput

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.

06-11-2017

The Journal of cell biology

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

06-11-2017

Nature

Association analysis identifies 65 new breast cancer risk loci.

02-11-2017

Clinical pharmacology and therapeutics

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.

01-11-2017

Cancer research

Computational Radiomics System to Decode the Radiographic Phenotype.

01-11-2017

European journal of cancer (Oxford, England : 1990)

Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma.

01-11-2017

Arteriosclerosis, thrombosis, and vascular biology

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

01-11-2017

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20).

01-11-2017

Urology

Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

01-11-2017

Breast cancer research and treatment

Pharmaceutically treated anxiety but not depression prior to cancer diagnosis predicts the onset of cardiovascular disease among breast cancer survivors.

01-11-2017

European journal of cancer (Oxford, England : 1990)

Elderly patients with gastrointestinal stromal tumour (GIST) receive less treatment irrespective of performance score or comorbidity - A retrospective multicentre study in a large cohort of GIST patients.

01-11-2017

International journal of cancer

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.

01-11-2017

JCO precision oncology

Profound Immunotherapy Response in Mismatch Repair-Deficient Breast Cancer.

01-11-2017

Abdominal radiology (New York)

Whole-volume vs. segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases.

01-11-2017

The Journal of antimicrobial chemotherapy

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

01-11-2017

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Patient-reported (EORTC QLQ-CIPN20) versus physician-reported (CTCAE) quantification of oxaliplatin- and paclitaxel/carboplatin-induced peripheral neuropathy in NCCTG/Alliance clinical trials.

01-11-2017

Breast cancer research and treatment

The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study.

01-11-2017

Advances in anatomic pathology

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.

01-11-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER⁺/HER2^- Breast Cancer.

01-11-2017

Archives of physical medicine and rehabilitation

Validation and Refinement of Prediction Models to Estimate Exercise Capacity in Cancer Survivors Using the Steep Ramp Test.

01-11-2017

Hepatology (Baltimore, Md.)

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.

01-11-2017

European journal of cancer (Oxford, England : 1990)

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir.

01-11-2017

The Lancet. Oncology

Extended adjuvant aromatase inhibition after sequential endocrine therapy (DATA): a randomised, phase 3 trial.

01-11-2017

Annals of surgical oncology

Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials.

01-11-2017

Nature cell biology

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

01-11-2017

Cancer research

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

01-11-2017

European journal of cancer care

Participation rates of childhood cancer survivors to self-administered questionnaires: a systematic review.

01-11-2017

European journal of cancer (Oxford, England : 1990)

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

01-11-2017

Journal of pharmaceutical and biomedical analysis

Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine.

25-10-2017

Oncotarget

BCRP expression in schwannoma, plexiform neurofibroma and MPNST.

24-10-2017

Cell reports

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression.

24-10-2017

Blood advances

Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitor.

24-10-2017

Lancet (London, England)

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006).

21-10-2017

Oncotarget

Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.

20-10-2017

Annals of internal medicine

Screening for Colorectal Cancer With Fecal Immunochemical Testing With and Without Postpolypectomy Surveillance Colonoscopy: A Cost-Effectiveness Analysis.

17-10-2017

Cell reports

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.

17-10-2017

Nutrition and cancer

The Impact of Body Mass Index and Waist Circumference on Health-related Quality of Life Among Colorectal Cancer Survivors: Results from the PROFILES Registry.

17-10-2017

Nature

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

12-10-2017

Cell host & microbe

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

11-10-2017

Nature biotechnology

Antigen receptor repertoire profiling from RNA-seq data.

11-10-2017

Science (New York, N.Y.)

Neutrophils take a round-trip.

06-10-2017

The New England journal of medicine

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

05-10-2017

Molecular pharmaceutics

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

02-10-2017

Journal of the National Cancer Institute

Post-traumatic Stress as the Primary Cause for Cognitive Decline-Not the Whole Story, and Perhaps No Story at All.

01-10-2017

Current opinion in chemical biology

A three-step framework for programming pattern formation.

01-10-2017

Human mutation

Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and mislocalization of granule proteins in neutrophils.

01-10-2017

Clinical and translational radiation oncology

A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor response.

01-10-2017

Genome research

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

01-10-2017

European journal of cancer (Oxford, England : 1990)

Hormone replacement therapy after risk-reducing salpingo-oophorectomy minimises endocrine and sexual problems: A prospective study.

01-10-2017

Lung cancer (Amsterdam, Netherlands)

Outcome of radical local treatment of non-small cell lung cancer patients with synchronous oligometastases.

01-10-2017

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

Association analysis identifies 65 new breast cancer risk loci.

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.

Computational Radiomics System to Decode the Radiographic Phenotype.

Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma.

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20).

Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

Pharmaceutically treated anxiety but not depression prior to cancer diagnosis predicts the onset of cardiovascular disease among breast cancer survivors.

Elderly patients with gastrointestinal stromal tumour (GIST) receive less treatment irrespective of performance score or comorbidity - A retrospective multicentre study in a large cohort of GIST patients.

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.

Profound Immunotherapy Response in Mismatch Repair-Deficient Breast Cancer.

Whole-volume vs. segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases.

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

Patient-reported (EORTC QLQ-CIPN20) versus physician-reported (CTCAE) quantification of oxaliplatin- and paclitaxel/carboplatin-induced peripheral neuropathy in NCCTG/Alliance clinical trials.

The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study.

Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER+/HER2- Breast Cancer.

Validation and Refinement of Prediction Models to Estimate Exercise Capacity in Cancer Survivors Using the Steep Ramp Test.

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir.

Extended adjuvant aromatase inhibition after sequential endocrine therapy (DATA): a randomised, phase 3 trial.

Surgical Upstaging Rates for Vacuum Assisted Biopsy Proven DCIS: Implications for Active Surveillance Trials.

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Participation rates of childhood cancer survivors to self-administered questionnaires: a systematic review.

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine.

BCRP expression in schwannoma, plexiform neurofibroma and MPNST.

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression.

Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitor.

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006).

Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.

Screening for Colorectal Cancer With Fecal Immunochemical Testing With and Without Postpolypectomy Surveillance Colonoscopy: A Cost-Effectiveness Analysis.

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.

The Impact of Body Mass Index and Waist Circumference on Health-related Quality of Life Among Colorectal Cancer Survivors: Results from the PROFILES Registry.

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.

Antigen receptor repertoire profiling from RNA-seq data.

Neutrophils take a round-trip.

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma.

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

Post-traumatic Stress as the Primary Cause for Cognitive Decline-Not the Whole Story, and Perhaps No Story at All.

A three-step framework for programming pattern formation.

Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and mislocalization of granule proteins in neutrophils.

A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor response.

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

Hormone replacement therapy after risk-reducing salpingo-oophorectomy minimises endocrine and sexual problems: A prospective study.

Outcome of radical local treatment of non-small cell lung cancer patients with synchronous oligometastases.

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Complementary Value of Contralateral Parenchymal Enhancement on DCE-MRI to Prognostic Models and Molecular Assays in High-risk ER⁺/HER2^- Breast Cancer.