Publications

Molecular pharmacology

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

01-04-2001

Clinical cancer research : an official journal of the American Association for Cancer Research

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

01-04-2001

Anti-cancer drugs

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

01-04-2001

Biopharmaceutics & drug disposition

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

01-04-2001

International journal of radiation oncology, biology, physics

Apoptosis, proliferation and p53, cyclin D1, and retinoblastoma gene expression in relation to radiation response in transitional cell carcinoma of the bladder.

01-04-2001

Toxicology letters

The importance of drug-transporting P-glycoproteins in toxicology.

31-03-2001

JAMA

The patient-physician relationship. Patient-physician communication during outpatient palliative treatment visits: an observational study.

14-03-2001

Nederlands tijdschrift voor geneeskunde

[Save or destroy? The importance of medical record for former patients and future patients].

10-03-2001

Experimental cell research

Mouse models for sporadic cancer.

10-03-2001

Anti-cancer drugs

Ras biochemistry and farnesyl transferase inhibitors: a literature survey.

01-03-2001

Studies in health technology and informatics

The development of a new information model for a pediatric cancer registry on late treatment sequelae in The Netherlands.

24-02-2001

Annals of the New York Academy of Sciences

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.

24-02-2001

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

15-02-2001

Journal of immunology (Baltimore, Md. : 1950)

A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function.

15-02-2001

Nature cell biology

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

01-02-2001

International journal of radiation oncology, biology, physics

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

01-02-2001

Current opinion in structural biology

DNA mismatch repair: MutS structures bound to mismatches.

01-02-2001

The Journal of urology

Comparison of patient and spouse assessments of health related quality of life in men with metastatic prostate cancer.

01-02-2001

Biochemical and biophysical research communications

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

26-01-2001

Current biology : CB

Galpha(13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells.

23-01-2001

British journal of cancer

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.

05-01-2001

British journal of clinical pharmacology

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.

01-01-2001

Clinical pharmacokinetics

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.

01-01-2001

Current oncology reports

Concurrent chemotherapy and radiation for locally advanced squamous cell cancers: what is the schedule of choice?

01-01-2001

Journal of neuro-oncology

Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.

01-01-2001

The Journal of cell biology

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.

25-12-2000

Proceedings of the National Academy of Sciences of the United States of America

Changing T cell specificity by retroviral T cell receptor display.

19-12-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

01-12-2000

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

01-12-2000

The Journal of biological chemistry

Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens.

03-11-2000

Anti-cancer drugs

Pharmaceutical development of anticancer agents derived from marine sources.

01-11-2000

Clinical cancer research : an official journal of the American Association for Cancer Research

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

01-11-2000

Nature genetics

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

01-11-2000

Clinical pharmacokinetics

Pharmacokinetically guided administration of chemotherapeutic agents.

01-11-2000

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

01-11-2000

Nature immunology

CD27 is required for generation and long-term maintenance of T cell immunity.

01-11-2000

Anti-cancer drugs

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

01-11-2000

Journal of the National Cancer Institute

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

18-10-2000

Cancer research

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

15-10-2000

Nature

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

12-10-2000

Oncogene

p27kip1-independent cell cycle regulation by MYC.

05-10-2000

Cancer gene therapy

Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome

01-10-2000

Anti-cancer drugs

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.

01-10-2000

Therapeutic drug monitoring

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection.

01-10-2000

Radiation research

In vitro and in vivo expression of endothelial von Willebrand factor and leukocyte accumulation after fractionated irradiation.

01-10-2000

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

How are you feeling? Who wants to know? Patients' and oncologists' preferences for discussing health-related quality-of-life issues.

15-09-2000

Lancet (London, England)

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen.

09-09-2000

Cancer chemotherapy and pharmacology

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens.

06-09-2000

Nature medicine

In situ detection of virus- and tumor-specific T-cell immunity.

01-09-2000

Journal of chromatography. B, Biomedical sciences and applications

Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography.

18-08-2000

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.

Distribution of ifosfamide and metabolites between plasma and erythrocytes.

Apoptosis, proliferation and p53, cyclin D1, and retinoblastoma gene expression in relation to radiation response in transitional cell carcinoma of the bladder.

The importance of drug-transporting P-glycoproteins in toxicology.

The patient-physician relationship. Patient-physician communication during outpatient palliative treatment visits: an observational study.

[Save or destroy? The importance of medical record for former patients and future patients].

Mouse models for sporadic cancer.

Ras biochemistry and farnesyl transferase inhibitors: a literature survey.

The development of a new information model for a pediatric cancer registry on late treatment sequelae in The Netherlands.

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function.

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

DNA mismatch repair: MutS structures bound to mismatches.

Comparison of patient and spouse assessments of health related quality of life in men with metastatic prostate cancer.

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

Galpha(13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells.

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.

Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites.

Concurrent chemotherapy and radiation for locally advanced squamous cell cancers: what is the schedule of choice?

Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.

Changing T cell specificity by retroviral T cell receptor display.

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens.

Pharmaceutical development of anticancer agents derived from marine sources.

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

Pharmacokinetically guided administration of chemotherapeutic agents.

Extensive cytoreductive surgery combined with intra-operative intraperitoneal perfusion with cisplatin under hyperthermic conditions (OVHIPEC) in patients with recurrent ovarian cancer: a feasibility pilot.

CD27 is required for generation and long-term maintenance of T cell immunity.

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

p27kip1-independent cell cycle regulation by MYC.

Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome

Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.

Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection.

In vitro and in vivo expression of endothelial von Willebrand factor and leukocyte accumulation after fractionated irradiation.

How are you feeling? Who wants to know? Patients' and oncologists' preferences for discussing health-related quality-of-life issues.

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres' ALERT Group. Assessment of Liver and Endometrial cancer Risk following Tamoxifen.

Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens.

In situ detection of virus- and tumor-specific T-cell immunity.

Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography.

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