Publications

Science translational medicine

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

09-10-2019

Nature genetics

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

01-10-2019

Annals of oncology : official journal of the European Society for Medical Oncology

When is off-label off-road?

01-10-2019

Nature

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.

01-10-2019

Key Publication

Endocrine-related cancer

The molecular genetic make-up of male breast cancer.

01-10-2019

British journal of cancer

Molecular tumour boards and molecular diagnostics for patients with cancer in the Netherlands: experiences, challenges, and aspirations.

01-07-2019

ESMO open

Advancing molecular tumour boards: highly needed to maximise the impact of precision medicine.

25-06-2019

European journal of cancer (Oxford, England : 1990)

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology.

01-06-2019

Cell

Identifying Epistasis in Cancer Genomes: A Delicate Affair.

30-05-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients.

01-05-2019

Molecular oncology

Cancer Core Europe: A translational research infrastructure for a European mission on cancer.

01-03-2019

The EMBO journal

Long-term expanding human airway organoids for disease modeling.

15-02-2019

JCO precision oncology

Rationale and Design of the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

04-01-2019

Nature medicine

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.

01-01-2019

International journal of cancer

Detection of endogenously circulating mesenchymal stem cells in human cancer patients.

15-11-2018

European journal of cancer (Oxford, England : 1990)

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

01-11-2018

Cell

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

06-09-2018

Key Publication

JCO precision oncology

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL.

16-08-2018

Nederlands tijdschrift voor geneeskunde

[Ethical dilemmas in a general practitioner's clinic due to incidental findings resulting from whole genome sequencing].

15-06-2018

Nederlands tijdschrift voor geneeskunde

[Unsolicited genomic findings in daily clinical practice].

15-06-2018

Angiogenesis

Platelet function is disturbed by the angiogenesis inhibitors sunitinib and sorafenib, but unaffected by bevacizumab.

01-05-2018

Cancer chemotherapy and pharmacology

Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids.

01-05-2018

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

American Society of Clinical Oncology Statement: Biosimilars in Oncology.

20-04-2018

Psycho-oncology

Managing unsolicited findings in genomics: A qualitative interview study with cancer patients.

01-04-2018

Familial cancer

Cancer patients' intentions towards receiving unsolicited genetic information obtained using next-generation sequencing.

01-04-2018

Nephron

The von Hippel-Lindau Gene Is Required to Maintain Renal Proximal Tubule and Glomerulus Integrity in Zebrafish Larvae.

18-01-2018

Cell

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

11-01-2018

Trends in molecular medicine

Is It Our Duty To Hunt for Pathogenic Mutations?

01-01-2018

Annals of oncology : official journal of the European Society for Medical Oncology

Molecular Tumor Boards: current practice and future needs.

01-12-2017

The oncologist

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.

01-12-2017

The oncologist

Fixed Dosing of Monoclonal Antibodies in Oncology.

01-10-2017

Cell chemical biology

Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.

21-09-2017

Clinical cancer research : an official journal of the American Association for Cancer Research

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity.

15-09-2017

ESMO open

Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers.

30-08-2017

Oncotarget

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.

15-08-2017

Cancer research

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.

15-07-2017

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

01-05-2017

Annals of oncology : official journal of the European Society for Medical Oncology

Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

01-05-2017

JAMA oncology

Alternating Treatment With Pazopanib and Everolimus vs Continuous Pazopanib to Delay Disease Progression in Patients With Metastatic Clear Cell Renal Cell Cancer: The ROPETAR Randomized Clinical Trial.

01-04-2017

ESMO open

Career opportunities and benefits for young oncologists in the European Society for Medical Oncology (ESMO).

04-03-2017

Intravital

Intravital characterization of tumor cell migration in pancreatic cancer.

01-03-2017

Neoplasia (New York, N.Y.)

Randomized Phase III Study to Assess Efficacy and Safety of Adjuvant CAPOX with or without Bevacizumab in Patients after Resection of Colorectal Liver Metastases: HEPATICA study.

01-02-2017

The oncologist

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.

01-01-2017

Human mutation

Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing.

01-12-2016

ESMO open

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

16-11-2016

JAMA oncology

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review.

01-11-2016

European journal of human genetics : EJHG

Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.

01-10-2016

Oncogene

Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.

04-08-2016

Annals of oncology : official journal of the European Society for Medical Oncology

The time to progression ratio: a new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies.

01-08-2016

Cell reports

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

28-06-2016

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients.

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

When is off-label off-road?

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.

The molecular genetic make-up of male breast cancer.

Molecular tumour boards and molecular diagnostics for patients with cancer in the Netherlands: experiences, challenges, and aspirations.

Advancing molecular tumour boards: highly needed to maximise the impact of precision medicine.

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology.

Identifying Epistasis in Cancer Genomes: A Delicate Affair.

Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients.

Cancer Core Europe: A translational research infrastructure for a European mission on cancer.

Long-term expanding human airway organoids for disease modeling.

Rationale and Design of the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.

Detection of endogenously circulating mesenchymal stem cells in human cancer patients.

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL.

[Ethical dilemmas in a general practitioner's clinic due to incidental findings resulting from whole genome sequencing].

[Unsolicited genomic findings in daily clinical practice].

Platelet function is disturbed by the angiogenesis inhibitors sunitinib and sorafenib, but unaffected by bevacizumab.

Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids.

American Society of Clinical Oncology Statement: Biosimilars in Oncology.

Managing unsolicited findings in genomics: A qualitative interview study with cancer patients.

Cancer patients' intentions towards receiving unsolicited genetic information obtained using next-generation sequencing.

The von Hippel-Lindau Gene Is Required to Maintain Renal Proximal Tubule and Glomerulus Integrity in Zebrafish Larvae.

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Is It Our Duty To Hunt for Pathogenic Mutations?

Molecular Tumor Boards: current practice and future needs.

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.

Fixed Dosing of Monoclonal Antibodies in Oncology.

Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity.

Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers.

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape.

Alternating Treatment With Pazopanib and Everolimus vs Continuous Pazopanib to Delay Disease Progression in Patients With Metastatic Clear Cell Renal Cell Cancer: The ROPETAR Randomized Clinical Trial.

Career opportunities and benefits for young oncologists in the European Society for Medical Oncology (ESMO).

Intravital characterization of tumor cell migration in pancreatic cancer.

Randomized Phase III Study to Assess Efficacy and Safety of Adjuvant CAPOX with or without Bevacizumab in Patients after Resection of Colorectal Liver Metastases: HEPATICA study.

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.

Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing.

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review.

Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.

Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.

The time to progression ratio: a new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies.

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

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