Publications

ESMO open

The pathway alteration load is a pan-cancer determinant of outcome of targeted therapies: results from the Drug Rediscovery Protocol (DRUP).

01-01-2025

Nature genetics

Base editing screens define the genetic landscape of cancer drug resistance mechanisms.

01-11-2024

The New England journal of medicine

Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer.

06-06-2024

The oncologist

Efficacy and Safety of Panitumumab in Patients With RAF/RAS-Wild-Type Glioblastoma: Results From the Drug Rediscovery Protocol.

03-05-2024

European journal of cancer (Oxford, England : 1990)

Trastuzumab plus pertuzumab for HER2-amplified advanced colorectal cancer: Results from the drug rediscovery protocol (DRUP).

01-05-2024

Cell

Generating and using real-world data: A worthwhile uphill battle.

28-03-2024

Nature biotechnology

Identification of patient-specific CD4⁺ and CD8⁺ T cell neoantigens through HLA-unbiased genetic screens.

01-06-2023

Cancer chemotherapy and pharmacology

Efficacy and toxicity of vemurafenib and cobimetinib in relation to plasma concentrations, after administration via feeding tube in patients with BRAF-mutated thyroid cancer: a case series and review of literature.

01-07-2022

Cell reports. Medicine

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.

21-06-2022

Nature medicine

Delivering precision oncology to patients with cancer.

01-04-2022

Cancer discovery

Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.

01-08-2021

Nature medicine

Author Correction: Caring for patients with cancer in the COVID-19 era.

01-07-2020

Nature medicine

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

01-07-2020

Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020

Nature communications

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing.

05-06-2020

Nature medicine

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers.

01-04-2020

Nature communications

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

20-11-2019

Nature genetics

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

01-10-2019

Annals of oncology : official journal of the European Society for Medical Oncology

When is off-label off-road?

01-10-2019

ESMO open

Advancing molecular tumour boards: highly needed to maximise the impact of precision medicine.

25-06-2019

Annals of oncology : official journal of the European Society for Medical Oncology

Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients.

01-05-2019

Molecular oncology

Cancer Core Europe: A translational research infrastructure for a European mission on cancer.

01-03-2019

European journal of cancer (Oxford, England : 1990)

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

01-11-2018

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

American Society of Clinical Oncology Statement: Biosimilars in Oncology.

20-04-2018

Psycho-oncology

Managing unsolicited findings in genomics: A qualitative interview study with cancer patients.

01-04-2018

Cell chemical biology

Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.

21-09-2017

ESMO open

Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers.

30-08-2017

Cancer research

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.

15-07-2017

Human mutation

Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing.

01-12-2016

PloS one

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

27-02-2016

Proceedings of the National Academy of Sciences of the United States of America

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

27-10-2015

JAMA oncology

Let Them Eat Fish--Reply.

01-09-2015

JAMA oncology

Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil.

01-06-2015

Clinical cancer research : an official journal of the American Association for Cancer Research

Dose-response relationship in phase i clinical trials: a European Drug Development Network (EDDN) Collaboration Study.

15-11-2014

Proceedings of the National Academy of Sciences of the United States of America

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

20-05-2014

British journal of cancer

Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.

13-05-2014

Cancer treatment reviews

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials.

01-12-2011

Annals of oncology : official journal of the European Society for Medical Oncology

Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.

01-07-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.

01-06-2007

Pharmacological research

Clinical research on antiangiogenic therapy.

01-01-1998