Publications

European urology

Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer.

01-10-2011

Chembiochem : a European journal of chemical biology

Peptide-functionalized luminescent iridium complexes for lifetime imaging of CXCR4 expression.

16-08-2011

Translational oncology

Immunohistochemical detection of the CXCR4 expression in tumor tissue using the fluorescent peptide antagonist Ac-TZ14011-FITC.

01-08-2011

Bioconjugate chemistry

Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.

18-05-2011

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer.

01-04-2011

Epigenetics & chromatin

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.

03-02-2011

Journal of biomedical optics

Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model.

02-02-2011

Chembiochem : a European journal of chemical biology

A modified epigenetics toolbox to study histone modifications on the nucleosome core.

24-01-2011

Nanotechnology

(Non-targeted) radioactive/fluorescent nanoparticles and their potential in combined pre- and intraoperative imaging during sentinel lymph node resection.

03-12-2010

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model.

01-12-2010

Journal of cell science

Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei.

01-12-2010

Journal of biomedical optics

Tumor bracketing and safety margin estimation using multimodal marker seeds: a proof of concept.

09-11-2010

Bioconjugate chemistry

Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label.

20-10-2010

Nanotechnology

A self-assembled multimodal complex for combined pre- and intraoperative imaging of the sentinel lymph node.

03-09-2010

Biomaterials

Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging.

01-09-2010

Proceedings of the National Academy of Sciences of the United States of America

Recombination-induced tag exchange to track old and new proteins.

05-01-2010

Laboratory animals

Validation of intratracheal instillation of lung tumour cells in mice using single photon emission computed tomography/computed tomography imaging.

01-01-2010

Nucleic acids research

Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome.

01-11-2009

BMC molecular biology

Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.

28-07-2009

European journal of nuclear medicine and molecular imaging

Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

01-03-2009

Chembiochem : a European journal of chemical biology

Chemical biology approaches to probe the proteome.

15-12-2008

Molecular and cellular biology

Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.

01-06-2008

Nature structural & molecular biology

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states.

01-06-2008

Molecular pharmaceutics

Profiling proteasome activity in tissue with fluorescent probes.

22-08-2007

Proceedings of the National Academy of Sciences of the United States of America

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

17-07-2007

The Journal of biological chemistry

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.

05-01-2007

Genome biology

Histone modifications: from genome-wide maps to functional insights.

18-06-2005

The Journal of biological chemistry

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.

03-01-2003

Studies in health technology and informatics

The development of a new information model for a pediatric cancer registry on late treatment sequelae in The Netherlands.

24-02-2001

Molecular and biochemical parasitology

Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

01-07-2000

The EMBO journal

The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.

15-11-1999

Nature cell biology

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading.

01-08-1999

Molecular and cellular biology

Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

01-10-1998

Molecular and biochemical parasitology

The modified DNA base beta-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei.

01-07-1998

Molecular and biochemical parasitology

Changes in expression site control and DNA modification in Trypanosoma brucei during differentiation of the bloodstream form to the procyclic form.

15-05-1998

Analytical biochemistry

The modified DNA base beta-D-glucosylhydroxymethyluracil confers resistance to micrococcal nuclease and is incompletely recovered by 32P-postlabeling.

01-05-1998

Proceedings of the National Academy of Sciences of the United States of America

beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

03-03-1998

Molecular and biochemical parasitology

Control of VSG gene expression sites in Trypanosoma brucei.

01-03-1998

Molecular and biochemical parasitology

beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

01-12-1997

Genes & development

Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei.

01-12-1997

The Journal of biological chemistry

Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain.

07-11-1997

The Journal of cell biology

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

03-11-1997

Behring Institute Mitteilungen

Mechanisms of antigenic variation in African trypanosomes.

01-03-1997

Nucleic acids research

The telomeric GGGTTA repeats of Trypanosoma brucei contain the hypermodified base J in both strands.

01-07-1996

Current topics in microbiology and immunology

Role of Tiam 1 in Rac-mediated signal transduction pathways.

01-01-1996

Archives of medical research

Antigenic variation in trypanosomes.

01-01-1996

Oncogene

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

07-12-1995

Cell

Antigenic variation in malaria.

14-07-1995

Cell

beta-D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. brucei.

17-12-1993

Cold Spring Harbor symposia on quantitative biology

Control of antigenic variation in African trypanosomes.

01-01-1993