Publications

Cancer research

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

01-11-2017

Nature

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

12-10-2017

Genome research

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

01-10-2017

BMC cancer

Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter study.

15-09-2017

EMBO molecular medicine

Phenotypic diversity drives paracrine drug tolerance.

01-08-2017

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

01-05-2017

Nature reviews. Cancer

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

01-04-2017

Oncotarget

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer.

15-03-2017

Oncotarget

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.

12-07-2016

Cell reports

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

28-06-2016

Oncotarget

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

07-06-2016

Oncotarget

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.

22-12-2015

Carcinogenesis

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence.

01-11-2015

Proceedings of the National Academy of Sciences of the United States of America

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

27-10-2015

Journal of proteome research

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

02-10-2015

EMBO molecular medicine

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.

01-09-2015

Molecular oncology

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

01-08-2015

Journal of proteome research

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

02-07-2015

Cell cycle (Georgetown, Tex.)

Two-way communication between the metabolic and cell cycle machineries: the molecular basis.

04-06-2015

Pigment cell & melanoma research

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

01-05-2015

Genome biology

CopywriteR: DNA copy number detection from off-target sequence data.

27-02-2015

Molecular systems biology

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.

23-12-2014

Nature communications

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.

15-12-2014

Cell reports

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

20-11-2014

Cancer research

Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy.

01-11-2014

Molecular oncology

Cancer drug resistance: old concept, novel solutions required.

12-09-2014

Molecular & cellular proteomics : MCP

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence.

01-08-2014

Pigment cell & melanoma research

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma.

01-07-2014

Nature

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

06-06-2013

Proceedings of the National Academy of Sciences of the United States of America

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

26-03-2013

Genes & development

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.

15-05-2012

Pigment cell & melanoma research

Oncogene-induced senescence and melanoma: where do we stand?

01-12-2011

The EMBO journal

C/EBPβ: lost beyond translation.

14-09-2011

Oncogene

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis.

01-09-2011

The EMBO journal

Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.

04-05-2011

PloS one

Functional characterization of human cancer-derived TRKB mutations.

17-02-2011

Genes & development

The essence of senescence.

15-11-2010

Aging

Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths.

01-10-2010

Cancer cell

PICS-ure this: prosenescence therapy?

16-03-2010

Carcinogenesis

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

01-02-2010

Biochimica et biophysica acta

Metastasis mechanisms.

01-12-2009

Molecular and cellular biology

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.

01-07-2009

PloS one

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.

14-05-2009

Cancer cell

Ras and pRb: the relationship gets yet more intimate.

07-04-2009

Nature reviews. Cancer

Senescence-messaging secretome: SMS-ing cellular stress.

01-02-2009

Cancer cell

Deregulating EMT and senescence: double impact by a single twist.

08-07-2008

Cell

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

13-06-2008

Current opinion in cell biology

Cellular senescence in vivo: a barrier to tumorigenesis.

01-04-2008

Oncogene

BRAF(E600) in benign and malignant human tumours.

07-02-2008

Cancer research

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis.

01-07-2007