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Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths.

Marjon A Smit ,
Daniel S Peeper

Abstract

The epithelial-mesenchymal transition is involved in several physiological processes. However, it is also believed to contribute to cancer progression. Conversely, cellular senescence constitutes a failsafe program against cancer progression. Interestingly, EMT and senescence seem to cross paths, with several factors playing dominant roles in both settings. Here, we describe recent observations that link these important cellular processes.

More about this publication

Aging

Volume 2
Issue nr. 10
Pages 735-41
Publication date 01-10-2010

Full text links

Publisher website (DOI) 10.18632/aging.100209
Europe PubMed Central 20975209
Pubmed 20975209

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