Publications

Nature genetics

Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers.

01-07-2025

Pharmacological research

Resistance to BRAF inhibitors drives melanoma sensitivity to Chk1 inhibition.

01-07-2025

Nucleic acids research

Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer.

11-12-2024

Cancer cell

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness.

08-04-2024

Cell reports

Phosphoprotein dynamics of interacting T cells and tumor cells by HySic.

23-01-2024

Frontiers in immunology

Heterogeneity in functional genetic screens: friend or foe?

03-07-2023

The EMBO journal

TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.

01-03-2023

Nature communications

Author Correction: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

07-02-2023

Nature

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-08-2022

Cell reports. Medicine

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.

21-06-2022

Nature communications

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling.

08-04-2022

Key

Immuno-oncology technology

The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens.

01-10-2021

Nature communications

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

07-08-2020

Journal of translational medicine

Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma.

03-07-2020

Molecular cell

Rational Cancer Treatment Combinations: An Urgent Clinical Need.

18-06-2020

Molecular & cellular proteomics : MCP

Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux.

01-02-2020

Cell

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

25-07-2019

The Lancet. Oncology

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial.

01-07-2019

JCI insight

Frequent clonal relations between metastases and non-index prostate cancer lesions.

24-01-2019

Genome research

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence.

01-10-2017

Oncotarget

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.

22-12-2015

Proceedings of the National Academy of Sciences of the United States of America

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases.

27-10-2015

Journal of proteome research

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

02-10-2015

Journal of proteome research

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

02-07-2015

Cell cycle (Georgetown, Tex.)

Two-way communication between the metabolic and cell cycle machineries: the molecular basis.

04-06-2015

Genome biology

CopywriteR: DNA copy number detection from off-target sequence data.

27-02-2015

Pigment cell & melanoma research

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma.

01-07-2014

Pigment cell & melanoma research

Oncogene-induced senescence and melanoma: where do we stand?

01-12-2011

PloS one

Functional characterization of human cancer-derived TRKB mutations.

17-02-2011

Cancer cell

PICS-ure this: prosenescence therapy?

16-03-2010

Carcinogenesis

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

01-02-2010

Cancer cell

Ras and pRb: the relationship gets yet more intimate.

07-04-2009

Cancer cell

Deregulating EMT and senescence: double impact by a single twist.

08-07-2008

Cell

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

13-06-2008

Cancer research

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis.

01-07-2007

Cancer research

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective.

15-08-2005

Nature

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.

26-08-2004

FEBS letters

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery.

23-06-1997