Publications

Nucleic acids research

Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution.

05-09-2025

Nature communications

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA.

30-07-2025

Molecular cell

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment.

19-12-2024

Nature communications

The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

29-07-2024

Journal of molecular biology

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain.

01-06-2024

Life science alliance

Variety in the USP deubiquitinase catalytic mechanism.

01-04-2024

Research square

DDA1, a novel factor in transcription-coupled repair, modulates CRL4^CSA dynamics at DNA damage-stalled RNA polymerase II.

12-10-2023

Nucleic acids research

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.

22-02-2023

Journal of structural biology

Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.

01-09-2022

Science advances

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.

29-07-2022

EMBO reports

AI revolutions in biology: The joys and perils of AlphaFold.

04-11-2021

PloS one

Proteomic analysis identifies novel binding partners of BAP1.

01-10-2021

EMBO reports

Insert L1 is a central hub for allosteric regulation of USP1 activity.

07-04-2021

Nature structural & molecular biology

The selection process of licensing a DNA mismatch for repair.

01-04-2021

Cell chemical biology

K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.

18-02-2021

The Journal of biological chemistry

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.

25-09-2020

Biochemistry and biophysics reports

Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1.

01-03-2020

Nucleic acids research

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.

16-12-2019

Nucleic acids research

Sharp kinking of a coiled-coil in MutS allows DNA binding and release.

19-09-2019

Nature communications

Structural basis of specific H2A K13/K15 ubiquitination by RNF168.

15-04-2019

Methods in enzymology

Quantitative analysis of USP activity in vitro.

10-03-2019

Nature communications

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

16-01-2019

EMBO reports

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

01-10-2018

Molecular cell

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

05-04-2018

Nature communications

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

15-01-2018

Journal of molecular biology

Regulation of USP7: A High Incidence of E3 Complexes.

10-11-2017

DNA repair

Histone ubiquitination in the DNA damage response.

01-08-2017

Methods in enzymology

Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair.

03-07-2017

The EMBO journal

USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.

01-06-2017

Journal of structural biology

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

01-12-2016

Journal of structural biology

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.

01-07-2016

Proceedings of the National Academy of Sciences of the United States of America

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells.

12-04-2016

The EMBO journal

Touch, act and go: landing and operating on nucleosomes.

15-02-2016

DNA repair

The conserved molecular machinery in DNA mismatch repair enzyme structures.

01-02-2016

The Journal of biological chemistry

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.

08-01-2016

Nature communications

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

07-01-2016

Nature

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

19-11-2015

Trends in biochemical sciences

Layers of DUB regulation.

01-08-2015

eLife

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

11-07-2015

Molecular cell

Make them, break them, and catch them: studying rare ubiquitin chains.

02-04-2015

Molecular cell

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

05-03-2015

Proceedings of the National Academy of Sciences of the United States of America

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.

03-03-2015

Nature communications

The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.

18-11-2014

Nature structural & molecular biology

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.

01-04-2014

Nature communications

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

13-02-2014

EMBO reports

RBR E3-ligases at work.

01-02-2014

Nucleic acids research

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.

01-09-2013

Nature communications

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

23-05-2013

The Journal of biological chemistry

Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

09-11-2012

The EMBO journal

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

03-10-2012

Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution.

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA.

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment.

The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain.

Variety in the USP deubiquitinase catalytic mechanism.

DDA1, a novel factor in transcription-coupled repair, modulates CRL4CSA dynamics at DNA damage-stalled RNA polymerase II.

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.

Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.

AI revolutions in biology: The joys and perils of AlphaFold.

Proteomic analysis identifies novel binding partners of BAP1.

Insert L1 is a central hub for allosteric regulation of USP1 activity.

The selection process of licensing a DNA mismatch for repair.

K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.

Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1.

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.

Sharp kinking of a coiled-coil in MutS allows DNA binding and release.

Structural basis of specific H2A K13/K15 ubiquitination by RNF168.

Quantitative analysis of USP activity in vitro.

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

Regulation of USP7: A High Incidence of E3 Complexes.

Histone ubiquitination in the DNA damage response.

Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair.

USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells.

Touch, act and go: landing and operating on nucleosomes.

The conserved molecular machinery in DNA mismatch repair enzyme structures.

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Layers of DUB regulation.

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

Make them, break them, and catch them: studying rare ubiquitin chains.

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.

The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

RBR E3-ligases at work.

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

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The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.

DDA1, a novel factor in transcription-coupled repair, modulates CRL4^CSA dynamics at DNA damage-stalled RNA polymerase II.