Publications

Life science alliance

Variety in the USP deubiquitinase catalytic mechanism.

01-04-2024

Research square

DDA1, a novel factor in transcription-coupled repair, modulates CRL4^CSA dynamics at DNA damage-stalled RNA polymerase II.

12-10-2023

Nucleic acids research

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding.

22-02-2023

Journal of structural biology

Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain.

01-09-2022

Science advances

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.

29-07-2022

EMBO reports

AI revolutions in biology: The joys and perils of AlphaFold.

04-11-2021

PloS one

Proteomic analysis identifies novel binding partners of BAP1.

01-10-2021

EMBO reports

Insert L1 is a central hub for allosteric regulation of USP1 activity.

07-04-2021

Nature structural & molecular biology

The selection process of licensing a DNA mismatch for repair.

01-04-2021

Cell chemical biology

K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.

18-02-2021

The Journal of biological chemistry

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.

25-09-2020

Biochemistry and biophysics reports

Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1.

01-03-2020

Nucleic acids research

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.

16-12-2019

Nucleic acids research

Sharp kinking of a coiled-coil in MutS allows DNA binding and release.

19-09-2019

Nature communications

Structural basis of specific H2A K13/K15 ubiquitination by RNF168.

15-04-2019

Methods in enzymology

Quantitative analysis of USP activity in vitro.

10-03-2019

Nature communications

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

16-01-2019

EMBO reports

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

01-10-2018

Molecular cell

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

05-04-2018

Nature communications

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

15-01-2018

Journal of molecular biology

Regulation of USP7: A High Incidence of E3 Complexes.

10-11-2017

DNA repair

Histone ubiquitination in the DNA damage response.

01-08-2017

Methods in enzymology

Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair.

03-07-2017

The EMBO journal

USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.

01-06-2017

Journal of structural biology

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.

01-12-2016

Journal of structural biology

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role.

01-07-2016

Proceedings of the National Academy of Sciences of the United States of America

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells.

12-04-2016

The EMBO journal

Touch, act and go: landing and operating on nucleosomes.

15-02-2016

DNA repair

The conserved molecular machinery in DNA mismatch repair enzyme structures.

01-02-2016

The Journal of biological chemistry

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.

08-01-2016

Nature communications

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

07-01-2016

Nature

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

19-11-2015

Trends in biochemical sciences

Layers of DUB regulation.

01-08-2015

eLife

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

11-07-2015

Molecular cell

Make them, break them, and catch them: studying rare ubiquitin chains.

02-04-2015

Molecular cell

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

05-03-2015

Proceedings of the National Academy of Sciences of the United States of America

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.

03-03-2015

Nature communications

The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.

18-11-2014

Nature structural & molecular biology

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.

01-04-2014

Nature communications

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

13-02-2014

EMBO reports

RBR E3-ligases at work.

01-02-2014

Nucleic acids research

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.

01-09-2013

Nature communications

Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein.

23-05-2013

The Journal of biological chemistry

Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

09-11-2012

The EMBO journal

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

03-10-2012

Cell

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

14-09-2012

The Journal of biological chemistry

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

06-07-2012

Biochemical Society transactions

The role of UBL domains in ubiquitin-specific proteases.

01-06-2012

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

01-05-2012

Chemistry & biology

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

23-12-2011