Publications

Cell

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

14-09-2012

The Journal of biological chemistry

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

06-07-2012

Biochemical Society transactions

The role of UBL domains in ubiquitin-specific proteases.

01-06-2012

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

01-05-2012

Chemistry & biology

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

23-12-2011

Molecular cell

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

07-10-2011

Journal of structural biology

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

01-08-2011

Proceedings of the National Academy of Sciences of the United States of America

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.

05-04-2011

EMBO reports

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.

01-04-2011

Angewandte Chemie (International ed. in English)

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.

27-12-2010

Journal of the American Chemical Society

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

07-07-2010

The Journal of biological chemistry

Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.

23-04-2010

Biochemical pharmacology

Insight in nAChR subtype selectivity from AChBP crystal structures.

01-10-2009

Journal of medicinal chemistry

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

23-04-2009

DNA repair

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

05-04-2009

Molecular cell

Ubc9 sumoylation regulates SUMO target discrimination.

08-08-2008

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement: the next generation.

01-01-2008

Current opinion in structural biology

Protein-protein interactions regulate Ubl conjugation.

01-12-2007

Nucleic acids research

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.

28-08-2007

The EMBO journal

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.

06-06-2007

The EMBO journal

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

07-06-2006

Proceedings of the National Academy of Sciences of the United States of America

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

07-03-2006

The EMBO journal

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

25-01-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

The Journal of biological chemistry

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

15-07-2005

Nature structural & molecular biology

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

01-07-2005

The Journal of biological chemistry

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

15-10-2004

Nucleic acids research

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA.

12-08-2004

Neuron

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

25-03-2004

Nucleic acids research

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.

15-08-2003

Annual review of biophysics and biomolecular structure

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

16-04-2003

The EMBO journal

The alternating ATPase domains of MutS control DNA mismatch repair.

03-02-2003

Novartis Foundation symposium

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

25-05-2002

Nature

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

17-05-2001

Current opinion in structural biology

DNA mismatch repair: MutS structures bound to mismatches.

01-02-2001

Nature

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

12-10-2000

The EMBO journal

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

01-10-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

Acta crystallographica. Section D, Biological crystallography

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

01-07-1997

Proceedings of the National Academy of Sciences of the United States of America

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.

18-03-1997