Publications

Cell

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

14-09-2012

The Journal of biological chemistry

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

06-07-2012

Biochemical Society transactions

The role of UBL domains in ubiquitin-specific proteases.

01-06-2012

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

01-05-2012

Chemistry & biology

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

23-12-2011

Molecular cell

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

07-10-2011

Journal of structural biology

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

01-08-2011

Proceedings of the National Academy of Sciences of the United States of America

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.

05-04-2011

EMBO reports

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.

01-04-2011

Angewandte Chemie (International ed. in English)

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.

27-12-2010

Journal of the American Chemical Society

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

07-07-2010

The Journal of biological chemistry

Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.

23-04-2010

Biochemical pharmacology

Insight in nAChR subtype selectivity from AChBP crystal structures.

01-10-2009

Journal of medicinal chemistry

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

23-04-2009

DNA repair

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

05-04-2009

Molecular cell

Ubc9 sumoylation regulates SUMO target discrimination.

08-08-2008

Acta crystallographica. Section D, Biological crystallography

ARP/wARP and molecular replacement: the next generation.

01-01-2008

Current opinion in structural biology

Protein-protein interactions regulate Ubl conjugation.

01-12-2007

Nucleic acids research

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.

28-08-2007

The EMBO journal

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.

06-06-2007

The EMBO journal

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

07-06-2006

Proceedings of the National Academy of Sciences of the United States of America

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

07-03-2006

The EMBO journal

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

25-01-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

The Journal of biological chemistry

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

15-07-2005

Nature structural & molecular biology

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

01-07-2005

The Journal of biological chemistry

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

15-10-2004

Nucleic acids research

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA.

12-08-2004

Neuron

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

25-03-2004

Nucleic acids research

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.

15-08-2003

Annual review of biophysics and biomolecular structure

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

16-04-2003

The EMBO journal

The alternating ATPase domains of MutS control DNA mismatch repair.

03-02-2003

Novartis Foundation symposium

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

25-05-2002

Nature

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

17-05-2001

Current opinion in structural biology

DNA mismatch repair: MutS structures bound to mismatches.

01-02-2001

Nature

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

12-10-2000

The EMBO journal

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

01-10-1997

The Journal of biological chemistry

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

22-08-1997

Acta crystallographica. Section D, Biological crystallography

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

01-07-1997

Proceedings of the National Academy of Sciences of the United States of America

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.

18-03-1997

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

The role of UBL domains in ubiquitin-specific proteases.

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases.

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.

Insight in nAChR subtype selectivity from AChBP crystal structures.

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

Ubc9 sumoylation regulates SUMO target discrimination.

ARP/wARP and molecular replacement: the next generation.

Protein-protein interactions regulate Ubl conjugation.

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

A genomic and functional inventory of deubiquitinating enzymes.

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA.

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates.

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

The alternating ATPase domains of MutS control DNA mismatch repair.

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

DNA mismatch repair: MutS structures bound to mismatches.

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein.

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