Publications

Blood

DOT1L Shapes ncPRC1-Target Gene Repression to Maintain Germinal Center B Cell Identity of Diffuse Large B cell Lymphoma.

29-05-2026

Trends in immunology

Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma.

01-02-2026

Science advances

Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.

12-12-2025

Neoplasia (New York, N.Y.)

Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.

01-12-2025

Blood

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma.

17-04-2025

Future oncology (London, England)

Advancing real-world research in thoracic malignancies: learnings from the international I-O Optimise initiative.

01-03-2025

Genome biology

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.

31-12-2024

Nucleic acids research

ADARp150 counteracts whole genome duplication.

23-09-2024

Oncogenesis

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.

11-07-2024

PNAS nexus

Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.

01-07-2024

Cellular & molecular immunology

CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

01-04-2024

International journal of molecular sciences

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

05-07-2023

Nature communications

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

17-04-2023

Frontiers in immunology

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

27-01-2023

Proceedings of the National Academy of Sciences of the United States of America

Mammalian life depends on two distinct pathways of DNA damage tolerance.

24-01-2023

International journal of molecular sciences

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model.

02-01-2023

Frontiers in genetics

DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro.

26-11-2022

Cell reports

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

22-11-2022

Nucleic acids research

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.

22-07-2022

Cell reports

Tumor-educated T_regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.

01-03-2022

eLife

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.

08-02-2022

Frontiers in immunology

Tandem Substitutions in Somatic Hypermutation.

25-01-2022

Cellular and molecular life sciences : CMLS

Signals for antigen-independent differentiation of memory CD8⁺ T cells.

01-10-2021

Frontiers in pharmacology

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

09-03-2021

EMBO reports

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

03-02-2021

Cell reports

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

29-12-2020

Proceedings of the National Academy of Sciences of the United States of America

The Ig heavy chain protein but not its message controls early B cell development.

08-12-2020

Proceedings of the National Academy of Sciences of the United States of America

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

25-08-2020

Frontiers in chemistry

Strategy for Development of Site-Specific Ubiquitin Antibodies.

11-03-2020

Frontiers in immunology

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.

12-09-2019

Nucleic acids research

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.

22-08-2019

The EMBO journal

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

15-07-2019

Oncogene

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

01-05-2019

Frontiers in immunology

Mutating for Good: DNA Damage Responses During Somatic Hypermutation.

28-03-2019

PloS one

Towards an understanding of C9orf82 protein/CAAP1 function.

11-01-2019

Oncotarget

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.

10-04-2018

Immunity

CD4⁺ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

21-11-2017

Molecular cell

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

07-09-2017

Proceedings of the National Academy of Sciences of the United States of America

DNA damage tolerance in hematopoietic stem and progenitor cells in mice.

15-08-2017

Proceedings of the National Academy of Sciences of the United States of America

Defining chromosomal translocation risks in cancer.

28-06-2016

Nucleic acids research

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

02-06-2016

Nucleic acids research

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

01-01-2015

Science (New York, N.Y.)

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

03-10-2014

Nucleic acids research

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light.

30-08-2014

The Journal of experimental medicine

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

25-08-2014

Haematologica

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.

01-08-2014

European journal of immunology

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

01-10-2013

PloS one

Differential programming of B cells in AID deficient mice.

08-08-2013

Science (New York, N.Y.)

Heterogeneous differentiation patterns of individual CD8+ T cells.

03-05-2013

The Journal of experimental medicine

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

08-04-2013

DOT1L Shapes ncPRC1-Target Gene Repression to Maintain Germinal Center B Cell Identity of Diffuse Large B cell Lymphoma.

Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma.

Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.

Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition.

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of diffuse large B-cell lymphoma.

Advancing real-world research in thoracic malignancies: learnings from the international I-O Optimise initiative.

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.

ADARp150 counteracts whole genome duplication.

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.

Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.

CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

Mammalian life depends on two distinct pathways of DNA damage tolerance.

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model.

DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro.

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.

Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.

Tandem Substitutions in Somatic Hypermutation.

Signals for antigen-independent differentiation of memory CD8+ T cells.

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

The Ig heavy chain protein but not its message controls early B cell development.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.

Strategy for Development of Site-Specific Ubiquitin Antibodies.

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

Mutating for Good: DNA Damage Responses During Somatic Hypermutation.

Towards an understanding of C9orf82 protein/CAAP1 function.

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.

CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

DNA damage tolerance in hematopoietic stem and progenitor cells in mice.

Defining chromosomal translocation risks in cancer.

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light.

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

Differential programming of B cells in AID deficient mice.

Heterogeneous differentiation patterns of individual CD8+ T cells.

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

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CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

Tumor-educated T_regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.

Signals for antigen-independent differentiation of memory CD8⁺ T cells.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

CD4⁺ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.