Publications

Cellular & molecular immunology

CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

01-04-2024

International journal of molecular sciences

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

05-07-2023

Nature communications

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

17-04-2023

Frontiers in immunology

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.

27-01-2023

Proceedings of the National Academy of Sciences of the United States of America

Mammalian life depends on two distinct pathways of DNA damage tolerance.

24-01-2023

International journal of molecular sciences

Chromosomal Rearrangements and Chromothripsis: The Alternative End Generation Model.

02-01-2023

Frontiers in genetics

DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro.

26-11-2022

Cell reports

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.

22-11-2022

Nucleic acids research

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.

22-07-2022

Cell reports

Tumor-educated T_regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche.

01-03-2022

eLife

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.

08-02-2022

Frontiers in immunology

Tandem Substitutions in Somatic Hypermutation.

25-01-2022

Cellular and molecular life sciences : CMLS

Signals for antigen-independent differentiation of memory CD8⁺ T cells.

01-10-2021

Frontiers in pharmacology

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

09-03-2021

EMBO reports

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.

03-02-2021

Cell reports

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

29-12-2020

Proceedings of the National Academy of Sciences of the United States of America

The Ig heavy chain protein but not its message controls early B cell development.

08-12-2020

Proceedings of the National Academy of Sciences of the United States of America

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells.

25-08-2020

Frontiers in chemistry

Strategy for Development of Site-Specific Ubiquitin Antibodies.

11-03-2020

Frontiers in immunology

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.

12-09-2019

Nucleic acids research

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.

22-08-2019

The EMBO journal

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

15-07-2019

Oncogene

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

01-05-2019

Frontiers in immunology

Mutating for Good: DNA Damage Responses During Somatic Hypermutation.

28-03-2019

PloS one

Towards an understanding of C9orf82 protein/CAAP1 function.

11-01-2019

Oncotarget

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.

10-04-2018

Immunity

CD4⁺ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness.

21-11-2017

Molecular cell

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

07-09-2017

Proceedings of the National Academy of Sciences of the United States of America

DNA damage tolerance in hematopoietic stem and progenitor cells in mice.

15-08-2017

Proceedings of the National Academy of Sciences of the United States of America

Defining chromosomal translocation risks in cancer.

28-06-2016

Nucleic acids research

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.

02-06-2016

Nucleic acids research

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

01-01-2015

Science (New York, N.Y.)

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

03-10-2014

Nucleic acids research

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light.

30-08-2014

The Journal of experimental medicine

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

25-08-2014

Haematologica

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.

01-08-2014

European journal of immunology

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

01-10-2013

PloS one

Differential programming of B cells in AID deficient mice.

08-08-2013

Science (New York, N.Y.)

Heterogeneous differentiation patterns of individual CD8+ T cells.

03-05-2013

The Journal of experimental medicine

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

08-04-2013

Blood

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

14-03-2013

Immunity

The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity.

24-01-2013

DNA repair

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

10-10-2011

DNA repair

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.

03-04-2011

PloS one

Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.

31-01-2011

PloS one

The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.

29-12-2010

The Journal of experimental medicine

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

23-11-2009

Blood

Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

10-09-2009

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

12-03-2009

The Journal of experimental medicine

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

06-08-2007