Publications

Nature cell biology

Structural organization and function of telomeric chromatin.

Nature communications

OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1^S824.

Nature communications

UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168.

Molecular cell

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants.

Molecular cell

Freedom to err: The expanding cellular functions of translesion DNA polymerases.

Bio-protocol

Quantification of Chromosomal Aberrations in Mammalian Cells.

Molecular & cellular proteomics : MCP

Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control.

Journal of lipid research

Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis.

Nature communications

MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner.

Nature communications

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.

Trends in cell biology

REV7: Jack of many trades.

Oncogene

H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres.

Nature cell biology

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.

Cell reports

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

Cell cycle (Georgetown, Tex.)

H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.

Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction

Clinical cancer research : an official journal of the American Association for Cancer Research

Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells.

Molecular cell

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.

Nature

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.

Frontiers in oncology

Loss of telomere protection: consequences and opportunities.

Nature reviews. Molecular cell biology

Senescence: back to telomeres.

Nature reviews. Molecular cell biology

Senescence: back to telomeres.

Cell cycle (Georgetown, Tex.)

Posttranslational control of telomere maintenance and the telomere damage response.

Nucleus (Austin, Tex.)

Fusing telomeres with RNF8.

Nature cell biology

DNA-damage response and repair activities at uncapped telomeres depend on RNF8.

Oncogene

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

Cell cycle (Georgetown, Tex.)

p16INK4a as a second effector of the telomere damage pathway.

Genes & development

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

The Journal of biological chemistry

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

Biochimica et biophysica acta

Polycomb repression: from cellular memory to cellular proliferation and cancer.

Nature genetics

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

Genes & development

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

Seminars in cell & developmental biology

Cellular memory of transcriptional states by Polycomb-group proteins.

Nature

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.

Journal of molecular biology

MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.

A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor

Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene