Publications

Cell reports

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.

21-08-2018

Molecular oncology

Loss of androgen receptor signaling in prostate cancer-associated fibroblasts (CAFs) promotes CCL2- and CXCL8-mediated cancer cell migration.

01-08-2018

Endocrine-related cancer

Androgen receptor moonlighting in the prostate cancer microenvironment.

01-06-2018

Life science alliance

ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1.

01-06-2018

Clinical cancer research : an official journal of the American Association for Cancer Research

Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses.

01-04-2018

Nature communications

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer.

02-02-2018

Oncogene

Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis.

18-01-2018

Nature communications

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

30-11-2017

Oncotarget

Loss of steroid hormone receptors is common in malignant pleural and peritoneal effusions of breast cancer patients treated with endocrine therapy.

15-08-2017

Lung cancer (Amsterdam, Netherlands)

Targeting BAP1: a new paradigm for mesothelioma.

01-07-2017

Endocrine-related cancer

A review of estrogen receptor/androgen receptor genomics in male breast cancer.

01-03-2017

Proceedings of the National Academy of Sciences of the United States of America

Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors.

21-02-2017

Breast cancer research and treatment

An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.

01-02-2017

Molecular endocrinology (Baltimore, Md.)

The Estrogen Receptor α-Cistrome Beyond Breast Cancer.

01-10-2016

Cancer research

Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas.

01-07-2016

Urology case reports

The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer.

01-07-2016

Oncotarget

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

07-06-2016

Oncotarget

mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma.

31-05-2016

Molecular cancer research : MCR

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.

01-05-2016

The Journal of endocrinology

The first decade of estrogen receptor cistromics in breast cancer.

01-05-2016

Genomics data

Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer.

01-03-2016

Nature biotechnology

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

01-02-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

15-01-2016

EMBO molecular medicine

Androgen receptor profiling predicts prostate cancer outcome.

01-11-2015

Cell reports

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

06-10-2015

Nature reviews. Clinical oncology

Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?

01-10-2015

BMC cancer

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

14-08-2015

Clinical pharmacokinetics

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

01-08-2015

Genomics data

Genome-wide epigenetic profiling of breast cancer tumors treated with aromatase inhibitors.

01-12-2014

Cancer research

Complex formation and function of estrogen receptor α in transcription requires RIP140.

01-10-2014

Cancer research

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

15-07-2014

Nucleic acids research

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

01-12-2013

Cancer research

Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

15-11-2013

European journal of pharmacology

Tamoxifen resistance: from bench to bedside.

05-10-2013

Breast cancer research and treatment

Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics.

01-08-2013

Oncogene

PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance.

25-07-2013

Nature communications

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

30-05-2013

Proceedings of the National Academy of Sciences of the United States of America

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

26-03-2013

Nature reviews. Clinical oncology

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

01-09-2012

The EMBO journal

Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer.

14-10-2011

Breast cancer research and treatment

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.

01-01-2011

Journal of cell science

The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells.

01-11-2010

Nature cell biology

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

01-10-2010

Journal of cell science

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

15-04-2010

Molecular endocrinology (Baltimore, Md.)

Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

01-09-2009

The Journal of cell biology

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.

29-06-2009

The EMBO journal

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

08-08-2007

Molecular cancer therapeutics

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

01-05-2007

Nuclear receptor signaling

Visualizing the action of steroid hormone receptors in living cells.

09-03-2007

Current opinion in microbiology

Presenting antigen presentation in living cells using biophysical techniques.

01-06-2005