Publications

Cancer research

Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production.

15-07-2026

Pharmacological research

Daraxonrasib (RMC-6236) pharmacokinetics: impact of transporters and drug-metabolizing enzymes on a first-in-class pan-RAS molecular glue.

01-07-2026

Cell death discovery

Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer.

27-06-2026

Mechanisms of ageing and development

Antiretroviral raltegravir, a selective human immunodeficiency virus type 1 integrase inhibitor, shows anti-Alzheimer's potential against amyloid-beta_1-42-induced neurodegeneration.

01-06-2026

Cancer research

C-Terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3.

16-03-2026

Scientific reports

Effect of curcumin on the gut microbiota of patients with ulcerative colitis, Crohn's disease and healthy participants.

01-03-2026

Cellular oncology (Dordrecht, Netherlands)

Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.

16-02-2026

Nature communications

Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.

02-12-2025

Neuro-oncology

Cranial radiotherapy profoundly affects glia without inducing widespread cellular senescence.

01-11-2025

Nature communications

Reanalysis of in vivo drug synergy validation study rules out synergy in most cases.

30-09-2025

iScience

A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability.

20-06-2025

Biomedical chromatography : BMC

Development and Validation of a Rapid and Simple LC-MS/MS Method for Quantification of the Anti-Microtubule, Anti-Cancer Agent ABT-751 in Human and Mouse Plasma and Mouse Tissues.

01-06-2025

Journal of Alzheimer's disease : JAD

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ_1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

01-05-2025

Cell death and differentiation

Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state.

01-05-2025

Immunity

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.

14-01-2025

Pharmaceuticals (Basel, Switzerland)

A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma.

14-12-2024

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method for simultaneous quantification of eight drugs in plasma and brain: Application in a pharmacokinetic study in mice.

15-10-2024

Communications biology

Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia.

04-10-2024

Fluids and barriers of the CNS

ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain.

05-08-2024

Cell reports. Medicine

The impact of ATP-binding cassette transporters in the diseased brain: Context matters.

18-06-2024

Molecular cancer

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients.

04-06-2024

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.

01-06-2024

Heliyon

Fractionated brain X-irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior in mice.

15-05-2024

Cell reports. Medicine

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.

19-03-2024

FEBS open bio

Acquired and intrinsic resistance to vemurafenib in BRAF^V600E -driven melanoma brain metastases.

01-01-2024

Frontiers in nutrition

Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life.

15-12-2023

Science advances

BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.

20-10-2023

Molecular oncology

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.

01-06-2023

Heliyon

A validated HPLC-MS/MS method for simultaneously analyzing curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetra-hydrocurcumin and piperine in human plasma, urine or feces.

01-05-2023

Cell reports

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.

25-04-2023

Pharmacological research

Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.

01-04-2023

Cell reports. Medicine

Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

15-11-2022

Cell reports. Medicine

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis.

15-11-2022

PloS one

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

07-09-2022

Nature

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-08-2022

Oncogene

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors.

01-08-2022

Genes

Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib.

04-07-2022

STAR protocols

Protocol for live-cell imaging during Tumor Treating Fields treatment with Inovitro Live.

17-06-2022

Nature

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-03-2022

Clinica chimica acta; international journal of clinical chemistry

Retrospective analysis of serum testosterone levels by LC-MS/MS in chemically castrated prostate cancer patients: Biological variation and analytical performance specifications.

01-10-2021

Molecular cancer therapeutics

ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib.

01-06-2021

Cell reports. Medicine

ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.

19-01-2021

Neuro-oncology

Comments on: "Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity".

29-09-2020

Clinical cancer research : an official journal of the American Association for Cancer Research

Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma.

01-07-2020

Proceedings of the National Academy of Sciences of the United States of America

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

30-06-2020

Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020

Journal of neuropathology and experimental neurology

Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients.

01-03-2020

Neuro-oncology

MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors.

11-01-2020

The EMBO journal

SLC1A3 contributes to L-asparaginase resistance in solid tumors.

04-10-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.

15-07-2019

Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production.

Daraxonrasib (RMC-6236) pharmacokinetics: impact of transporters and drug-metabolizing enzymes on a first-in-class pan-RAS molecular glue.

Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer.

Antiretroviral raltegravir, a selective human immunodeficiency virus type 1 integrase inhibitor, shows anti-Alzheimer's potential against amyloid-beta1-42-induced neurodegeneration.

C-Terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3.

Effect of curcumin on the gut microbiota of patients with ulcerative colitis, Crohn's disease and healthy participants.

Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma.

Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.

Cranial radiotherapy profoundly affects glia without inducing widespread cellular senescence.

Reanalysis of in vivo drug synergy validation study rules out synergy in most cases.

A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability.

Development and Validation of a Rapid and Simple LC-MS/MS Method for Quantification of the Anti-Microtubule, Anti-Cancer Agent ABT-751 in Human and Mouse Plasma and Mouse Tissues.

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state.

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation.

A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma.

Development and validation of an LC-MS/MS method for simultaneous quantification of eight drugs in plasma and brain: Application in a pharmacokinetic study in mice.

Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia.

ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain.

The impact of ATP-binding cassette transporters in the diseased brain: Context matters.

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients.

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.

Fractionated brain X-irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior in mice.

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.

Acquired and intrinsic resistance to vemurafenib in BRAFV600E -driven melanoma brain metastases.

Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life.

BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.

A validated HPLC-MS/MS method for simultaneously analyzing curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetra-hydrocurcumin and piperine in human plasma, urine or feces.

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.

Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.

Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis.

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors.

Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib.

Protocol for live-cell imaging during Tumor Treating Fields treatment with Inovitro Live.

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

Retrospective analysis of serum testosterone levels by LC-MS/MS in chemically castrated prostate cancer patients: Biological variation and analytical performance specifications.

ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib.

ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.

Comments on: "Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity".

Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma.

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients.

MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors.

SLC1A3 contributes to L-asparaginase resistance in solid tumors.

EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.

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Antiretroviral raltegravir, a selective human immunodeficiency virus type 1 integrase inhibitor, shows anti-Alzheimer's potential against amyloid-beta_1-42-induced neurodegeneration.

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ_1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

Acquired and intrinsic resistance to vemurafenib in BRAF^V600E -driven melanoma brain metastases.