Banner Publications MH200828 N141

Publications

Results found: 196

Showing results: 1 - 50

Communications biology

Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia.

04-10-2024
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Development and validation of an LC-MS/MS method for simultaneous quantification of eight drugs in plasma and brain: Application in a pharmacokinetic study in mice.

12-09-2024
Fluids and barriers of the CNS

ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain.

05-08-2024
Cell reports. Medicine

The impact of ATP-binding cassette transporters in the diseased brain: Context matters.

18-06-2024
Molecular cancer

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients.

04-06-2024
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.

01-06-2024
Heliyon

Fractionated brain X-irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior in mice.

15-05-2024
Cell reports. Medicine

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.

19-03-2024
FEBS open bio

Acquired and intrinsic resistance to vemurafenib in BRAFV600E -driven melanoma brain metastases.

01-01-2024
Frontiers in nutrition

Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life.

15-12-2023
Science advances

BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.

20-10-2023
Molecular oncology

Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.

01-06-2023
Heliyon

A validated HPLC-MS/MS method for simultaneously analyzing curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetra-hydrocurcumin and piperine in human plasma, urine or feces.

01-05-2023
Cell reports

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.

25-04-2023
Pharmacological research

Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.

01-04-2023
Cell reports. Medicine

Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.

15-11-2022
Cell reports. Medicine

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis.

15-11-2022
PloS one

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

07-09-2022
Nature

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-08-2022
Oncogene

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors.

01-08-2022
Genes

Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib.

04-07-2022
STAR protocols

Protocol for live-cell imaging during Tumor Treating Fields treatment with Inovitro Live.

17-06-2022
Nature

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

01-03-2022
Clinica chimica acta; international journal of clinical chemistry

Retrospective analysis of serum testosterone levels by LC-MS/MS in chemically castrated prostate cancer patients: Biological variation and analytical performance specifications.

01-10-2021
Molecular cancer therapeutics

ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib.

01-06-2021
Cell reports. Medicine

ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.

19-01-2021
Neuro-oncology

Comments on: "Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity".

29-09-2020
Clinical cancer research : an official journal of the American Association for Cancer Research

Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma.

01-07-2020
Nature communications

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours.

22-06-2020
Journal of neuropathology and experimental neurology

Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients.

01-03-2020
Neuro-oncology

MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors.

11-01-2020
The EMBO journal

SLC1A3 contributes to L-asparaginase resistance in solid tumors.

04-10-2019
Clinical cancer research : an official journal of the American Association for Cancer Research

EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.

15-07-2019
Clinical cancer research : an official journal of the American Association for Cancer Research

MELK Inhibition in Diffuse Intrinsic Pontine Glioma.

15-11-2018
Molecular pharmaceutics

ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461.

05-11-2018
Trends in molecular medicine

An Experimenter's Guide to Glioblastoma Invasion Pathways.

01-09-2018
Scientific reports

Buparlisib is a brain penetrable pan-PI3K inhibitor.

17-07-2018
British journal of cancer

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

01-06-2018
Investigational new drugs

ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors.

01-06-2018
Journal of extracellular vesicles

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8.

27-04-2018
Methods in molecular biology (Clifton, N.J.)

Serum Testosterone by Liquid Chromatography Tandem Mass Spectrometry for Routine Clinical Diagnostics.

25-01-2018
International journal of cancer

The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors.

15-01-2018
Oncotarget

BCRP expression in schwannoma, plexiform neurofibroma and MPNST.

24-10-2017
Cell reports

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness.

05-07-2017
Clinica chimica acta; international journal of clinical chemistry

A serum and platelet-rich plasma serotonin assay using liquid chromatography tandem mass spectrometry for monitoring of neuroendocrine tumor patients.

01-06-2017
FEBS open bio

The G2 checkpoint-a node-based molecular switch.

01-04-2017
Clinical cancer research : an official journal of the American Association for Cancer Research

PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.

01-03-2017
Drug delivery and translational research

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar.

01-02-2017
Journal of neurology

Strategies to target drugs to gliomas and CNS metastases of solid tumors.

01-03-2016
Nature

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.

25-02-2016

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