Publications

Cancer gene therapy

Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells.

01-04-2024

British journal of cancer

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma.

22-03-2024

Cancer research communications

Combined Inhibition of EZH2 and FGFR is Synergistic in BAP1-deficient Malignant Mesothelioma.

03-01-2024

Cell reports. Medicine

Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma.

21-02-2023

Breast cancer research : BCR

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer.

17-06-2022

International journal of molecular sciences

Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy.

28-08-2021

Cell reports

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

29-12-2020

The Journal of experimental medicine

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice.

01-06-2020

PloS one

A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition.

29-04-2020

Experimental hematology

Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.

01-08-2019

Clinical cancer research : an official journal of the American Association for Cancer Research

EZH2 Is Overexpressed in BRCA1-like Breast Tumors and Predictive for Sensitivity to High-Dose Platinum-Based Chemotherapy.

15-07-2019

Nature communications

Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency.

08-04-2019

The Journal of experimental medicine

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

03-12-2018

Transgenic research

A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2.

01-04-2017

Stem cells (Dayton, Ohio)

TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.

01-01-2017

Oncotarget

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition.

25-10-2016

Gastroenterology

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.

01-10-2016

Oncogene

Context-dependent actions of Polycomb repressors in cancer.

17-03-2016

Cancer cell

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

11-01-2016

Mobile genetic elements

Applications of DNA integrating elements: Facing the bias bully.

07-10-2015

Blood

Loss of PRDM11 promotes MYC-driven lymphomagenesis.

19-02-2015

Cell reports

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

20-01-2015

Nature protocols

In vivo shRNA screens in solid tumors.

01-12-2014

The Journal of experimental medicine

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

25-08-2014

Nature protocols

Using TRIP for genome-wide position effect analysis in cultured cells.

09-05-2014

PLoS genetics

Chromatin landscapes of retroviral and transposon integration profiles.

01-04-2014

Stem cells (Dayton, Ohio)

Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

01-09-2013

Cell

Chromatin position effects assayed by thousands of reporters integrated in parallel.

15-08-2013

The EMBO journal

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

29-05-2013

PloS one

Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors.

22-05-2013

Cancer cell

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

13-05-2013

Methods (San Diego, Calif.)

Chromosome conformation capture on chip in single Drosophila melanogaster tissues.

01-11-2012

Journal of cell science

The emerging role of Polycomb repressors in the response to DNA damage.

01-09-2012

Development (Cambridge, England)

The Polycomb group protein Ring1b is essential for pectoral fin development.

01-06-2012

PloS one

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

11-05-2012

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

01-05-2012

The Journal of experimental medicine

A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.

19-12-2011

Nucleic acids research

Computational identification of insertional mutagenesis targets for cancer gene discovery.

01-08-2011

Proceedings of the National Academy of Sciences of the United States of America

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish.

15-03-2011

PLoS genetics

Interactions among Polycomb domains are guided by chromosome architecture.

01-03-2011

Clinical cancer research : an official journal of the American Association for Cancer Research

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

01-07-2010

Molecular cell

Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation.

28-05-2010

Cancer research

Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

15-01-2010

Breast cancer research : BCR

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

28-08-2009

Nature protocols

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

17-06-2009

Nature

Bmi1 regulates mitochondrial function and the DNA damage response pathway.

21-05-2009

PloS one

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.

14-05-2009

Biochimica et biophysica acta

Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.

01-05-2009

Breast cancer research : BCR

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.

23-12-2008

Oncogene

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

20-11-2008