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Publications

Results found: 252

Showing results: 51 - 100

Nature communications

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

17-12-2018
EMBO molecular medicine

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

01-12-2018
Cancer metastasis reviews

Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment.

01-12-2018
BMC bioinformatics

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data.

04-10-2018
Cancer research

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547.

01-10-2018
The Journal of pathology

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

01-09-2018
Cancer cell

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations.

13-08-2018
Nature

The shieldin complex mediates 53BP1-dependent DNA repair.

01-08-2018
The Journal of pathology

αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.

01-08-2018
Open biology

Mouse models in the era of large human tumour sequencing studies.

01-08-2018
Cancer cell

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

11-06-2018
British journal of cancer

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

01-06-2018
Molecular oncology

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

01-06-2018
Nucleic acids research

Easy quantification of template-directed CRISPR/Cas9 editing.

01-06-2018
Cell reports

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

15-05-2018
Annals of oncology : official journal of the European Society for Medical Oncology

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.

01-05-2018
Cell reports

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.

03-04-2018
Cancer discovery

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

01-04-2018
Oncogene

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance.

01-03-2018
Nature methods

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

01-02-2018
Laboratory investigation; a journal of technical methods and pathology

Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β.

01-01-2018
Clinical cancer research : an official journal of the American Association for Cancer Research

Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice.

15-11-2017
Nature cell biology

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

01-11-2017
Cancer research

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

01-11-2017
Oncotarget

Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.

20-10-2017
EMBO molecular medicine

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.

01-10-2017
Oncotarget

Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice.

22-09-2017
Oncotarget

Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer.

15-08-2017
Nature genetics

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma.

01-08-2017
Nature communications

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

17-07-2017
Nucleic acids research

Identifying transposon insertions and their effects from RNA-sequencing data.

07-07-2017
Oncogene

p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

27-04-2017
Nature reviews. Cancer

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

01-04-2017
The Journal of pathology

Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.

01-03-2017
EMBO molecular medicine

Genetically engineered mouse models in oncology research and cancer medicine.

01-02-2017
Journal of mammary gland biology and neoplasia

p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice.

01-12-2016
Nature cell biology

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.

01-12-2016
Cold Spring Harbor symposia on quantitative biology

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

07-11-2016
Journal of the National Cancer Institute

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer.

01-11-2016
Cancer research

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.

15-10-2016
Oncotarget

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.

27-09-2016
Cell reports

PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma.

23-08-2016
J Clin Invest: The Journal of clinical investigation

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

25-07-2016
Nature

Replication fork stability confers chemoresistance in BRCA-deficient cells.

21-07-2016
Genes & development

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.

15-06-2016
Nature

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

02-06-2016
Cancer research

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

01-05-2016
Molecular cell

HELB Is a Feedback Inhibitor of DNA End Resection.

04-02-2016
Clinical cancer research : an official journal of the American Association for Cancer Research

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors.

01-01-2016
Nature protocols

Using the GEMM-ESC strategy to study gene function in mouse models.

01-11-2015

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