Publications

Cancer research

Chemotherapy-Treated Breast Cancer Cells Activate the WNT Signaling Pathway to Enter a Diapause-Like Early Persister State.

16-01-2026

Communications medicine

High-throughput spheroid-based assay for functional breast cancer precision medicine facilitated by deep learning.

10-01-2026

Nature genetics

Insights from three decades of BRCA1/2 modeling in mice.

06-01-2026

Cancer research

C-terminal Truncation and Fusion Partner Determine Oncogenicity of FGFR3.

29-12-2025

Oncogene

MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors.

17-12-2025

Mammalian genome : official journal of the International Mammalian Genome Society

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.

10-12-2025

Nature

Fasting boosts breast cancer therapy efficacy via glucocorticoid activation.

10-12-2025

ImmunoHorizons

BRCA1 deficiency leads to aberrant epithelial differentiation in the thymus.

24-11-2025

Communications biology

NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake.

06-10-2025

Cancer research

The C-Terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.

02-09-2025

Nature

NASP modulates histone turnover to drive PARP inhibitor resistance.

01-09-2025

Cancer research

Large-scale Characterization of Orthotopic Cell Line-Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness.

15-07-2025

Cancer cell

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets.

14-07-2025

Breast cancer research : BCR

Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma.

01-07-2025

Nucleic acids research

TRIP12's role in the governance of DNA polymerase β involvement in DNA damage response and repair.

20-06-2025

JCI insight

G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor.

09-06-2025

The Journal of clinical investigation

The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression.

02-06-2025

Cell reports

SRBD1, a highly conserved gene required for chromosome individualization.

22-04-2025

Cancer discovery

Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.

03-03-2025

Genes & development

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality.

07-01-2025

Nature

Mechanisms that clear mutations drive field cancerization in mammary tissue.

01-09-2024

The Journal of pathology

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts.

01-07-2024

Journal of mammary gland biology and neoplasia

Transcriptomic Analysis of Pubertal and Adult Virgin Mouse Mammary Epithelial and Stromal Cell Populations.

25-06-2024

Journal of mammary gland biology and neoplasia

Rat Models of Hormone Receptor-Positive Breast Cancer.

24-06-2024

Nature communications

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours.

24-05-2024

The EMBO journal

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.

01-03-2024

Breast cancer research : BCR

Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers.

19-02-2024

EMBO molecular medicine

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity.

07-12-2023

The Journal of experimental medicine

MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.

06-11-2023

Journal of mammary gland biology and neoplasia

Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.

06-10-2023

STAR protocols

Mouse intraductal modeling of primary ductal carcinoma in situ.

15-09-2023

Molecular cell

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.

03-08-2023

Clinical and translational medicine

MIND the translational gap: Preclinical models of ductal carcinoma in situ.

01-08-2023

Journal of mammary gland biology and neoplasia

Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research.

14-07-2023

Science advances

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks.

02-06-2023

Cell reports

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors.

30-05-2023

Nat. Commun: Nature Communications

Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

30-11-2020

Nat. Commun: Nature Communications

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

21-09-2020

Nat Commun.

Sex differences in oncogenic mutational processes

28-08-2020

Nat: Nature

Pan-cancer analysis of whole genomes

05-02-2020

J Clin Invest: The Journal of clinical investigation

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

25-07-2016

J Pathol.: The journal of pathology

Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase

23-01-2015

J Proteome Res.: Journal of proteome research

The use of mass spectrometry imaging to predict treatment response of patient-derived xenograft models of triple-negative breast cancer

20-01-2015

Nucleic Acids Res.: Nucleic Acids research

INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

20-11-2014

Breast Cancer Research: BRC

Genomic patterns resembling BRCA1- and BRCA2-mutated breast cancers predict benefit of intensified carboplatin-based chemotherapy

15-05-2014

Stem Cells (Dayton, Ohio)

Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminal

01-09-2013

J Exp Med.: The journal of experimental medicine

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

15-07-2013

Cancer Research

Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling

03-06-2013

Nat Commun.: Nature communications

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets

01-06-2013

Proc Natl Acad Sci U S A: Proceedings of the National Academy of Siences of the United States of America

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

08-05-2013