Equipment & technologies

The LAC consists of five independent microbiological units

The T3 breeding unit is dedicated to nucleus- and production breeding of transgenic unique mice strains under specific and opportunistic pathogen free (SOPF) conditions. This unit is only accessible for authorized staff of the animal facility to guarantee a clean and stable health status of the mice colonies. All mouse lines that are re-derived via caesarian section or embryo transfer, or recovered after cryopreservation from frozen sperm or embryos, are imported into this unit.
The T3 BSL2 unit is a negative barrier area for biosafety-level (BSL) 2 experiments and infection studies. Depending on the infectious agent, mice are housed in IVCs or isolators.
The T2 unit is a combined experimental and breeding unit where mice are kept under specific pathogen free (SPF) conditions. T2 supports the Animal Model facility that creates custom-made genetically engineered mouse strains for researchers and performs cryopreservation of mouse strains by freezing sperm or embryos.
The T1 unit is a negative barrier area that houses the Mouse Cancer Clinic for preclinical imaging and intervention studies with mice and rats. This unit is equipped with small-animal systems for image-guided radiation therapy (IGRT), bioluminescence and fluorescence imaging, MRI, PET-CT, SPECT-CT, and intra-vital imaging.
The T0 quarantine and sanitation unit is dedicated to importing mice from non-approved vendors or other research facilities. All mice are sanitized either via embryo transfer or caesarian section within a short time frame. Also small-scale ‘dirty’ experiments can be performed here.

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