Supercoiling Still

New research reveals how genes are regulated by DNA supercoiling


Overwinding or underwinding of DNA can inhibit neighboring genes, potentially affecting cancer and the interplay of gene regulation with DNA repair processes.

A new study by a team of researchers at the Netherlands Cancer Institute reveals a previously unknown way in which genes are regulated by the winding of DNA, known as DNA supercoiling. They found that when DNA supercoils accumulate, it can inhibit the reading of adjacent genes, throwing off the factors that bind to DNA and making reading less efficient. The study's findings could have important implications for understanding diseases like cancer and the processes that govern cell growth and response to signals.

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