High-dose chemotherapy in high-risk breast cancer shows improved survival in 20-year follow-up


The N4+ study was conducted at ten centres in the Netherlands by Prof. Sjoerd Rodenhuis (Netherlands Cancer Institute) and Prof. Liesbeth de Vries (UMCG) from 1993 to 1999. The study investigated the effectiveness of high-dose chemotherapy compared with conventional dose chemotherapy in 885 women with breast cancer and at least four positive lymph nodes in the armpit.

To allow the blood count to recover after high-dose chemotherapy the treatment was combined with an autologous stem cell transplant, where the patients' own stem cells were used.

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